The requirement of BDNF for hippocampal synaptic plasticity is experience-dependent.
The requirement of BDNF for hippocampal synaptic plasticity is experience-dependent.
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DOI：
10.1002/hipo.22555
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发表时间：
2016-06
期刊：
影响因子：
3.5
通讯作者：
Manahan-Vaughan, Denise
中科院分区：
文献类型：
--
作者：
Aarse, Janna;Herlitze, Stefan;Manahan-Vaughan, Denise
脑源性神经营养因子（BDNF）支持神经元的存活，生长和分化，并参与海马依赖性学习的形式。在体外，已经描述了海马突触可塑性中的特定作用，尽管并非所有经验依赖性形式的突触可塑性都严重依赖于BDNF。突触可塑性可能使长期突触信息存储和记忆成为可能，并且持续（>24小时）形式的诱导，如长时程增强（LTP）和长时程抑制（LTD）与学习空间表征的特定方面密切相关。持久（>24小时）形式的LTP和LTD是否需要脑源性神经营养因子，以及它如何对自由行为的啮齿动物的突触可塑性做出贡献，尚未被探索过。我们检测了部分敲除BDNF（BDNF+/−）的自由依赖小鼠的CA 1区的LTP、LTD和相关学习形式。我们发现，早期LTD（<90分钟）需要BDNF，而短期抑郁症（<45分钟）则不需要。此外，BDNF是LTP所必需的，LTP由温和但不强烈的短传入刺激方案诱导。物体位置学习触发小鼠CA 1区的LTD。我们观察到物体位置记忆受损，物体位置探索未能诱导BDNF+/−小鼠的LTD。此外，被认为是由LTP实现的空间参考记忆也受到了损害。总之，这些数据表明BDNF是特定的，但不是所有形式的海马依赖性信息存储和记忆所必需的。因此，非常强大的突触可塑性形式可能会绕过对BDNF的需求，而它可能在优化较弱形式的可塑性方面发挥特定作用。在BDNF+/−小鼠中，学习促进的LTD和空间参考记忆都受损，这一发现表明，它是海马依赖性记忆的生理编码所必需的。© 2015 The Authors Hippocampus由Wiley Periodicals，Inc.
Brain‐derived neurotrophic factor (BDNF) supports neuronal survival, growth, and differentiation and has been implicated in forms of hippocampus‐dependent learning. In vitro, a specific role in hippocampal synaptic plasticity has been described, although not all experience‐dependent forms of synaptic plasticity critically depend on BDNF. Synaptic plasticity is likely to enable long‐term synaptic information storage and memory, and the induction of persistent (>24 h) forms, such as long‐term potentiation (LTP) and long‐term depression (LTD) is tightly associated with learning specific aspects of a spatial representation. Whether BDNF is required for persistent (>24 h) forms of LTP and LTD, and how it contributes to synaptic plasticity in the freely behaving rodent has never been explored. We examined LTP, LTD, and related forms of learning in the CA1 region of freely dependent mice that have a partial knockdown of BDNF (BDNF+/−). We show that whereas early‐LTD (<90min) requires BDNF, short‐term depression (<45 min) does not. Furthermore, BDNF is required for LTP that is induced by mild, but not strong short afferent stimulation protocols. Object‐place learning triggers LTD in the CA1 region of mice. We observed that object‐place memory was impaired and the object‐place exploration failed to induce LTD in BDNF+/− mice. Furthermore, spatial reference memory, that is believed to be enabled by LTP, was also impaired. Taken together, these data indicate that BDNF is required for specific, but not all, forms of hippocampal‐dependent information storage and memory. Thus, very robust forms of synaptic plasticity may circumvent the need for BDNF, rather it may play a specific role in the optimization of weaker forms of plasticity. The finding that both learning‐facilitated LTD and spatial reference memory are both impaired in BDNF+/− mice, suggests moreover, that it is critically required for the physiological encoding of hippocampus‐dependent memory. © 2015 The Authors Hippocampus Published by Wiley Periodicals, Inc.
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