A Metabonomics Profiling Study on Phlegm Syndrome and Blood-Stasis Syndrome in Coronary Heart Disease Patients Using Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry.
A Metabonomics Profiling Study on Phlegm Syndrome and Blood-Stasis Syndrome in Coronary Heart Disease Patients Using Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry.
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液相色谱/四极杆飞行时间质谱法对冠心病痰证、血瘀证代谢组学分析研究
DOI：
10.1155/2014/385102
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Wang D
中科院分区：
文献类型：
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作者：
Zhao L;Wan L;Qiu X;Li R;Liu S;Wang D
采用液相色谱/四极杆飞行时间质谱（LC-Q-TOF/MS）代谢组学方法，筛选冠心病患者的潜在生物标志物，并探讨冠心病患者证型的差异。收集冠心病痰证患者20例，冠心病血瘀证患者20例，健康志愿者16例。冠心病患者血浆中有26个潜在的生物标志物，其中19个差异代谢产物（VIP > 1.5; P < 0.05）可用于冠心病痰瘀证的鉴别，主要涉及嘌呤代谢、嘧啶代谢、氨基酸代谢、类固醇生物合成和花生四烯酸代谢。本研究表明，基于LC-MS的代谢组学方法有助于研究冠心病患者的病理变化，并有助于解释中医证型（痰瘀证）的辨证。
A metabonomics approach based on liquid chromatography/quadrupole time-of-flight mass spectrometry (LC-Q-TOF/MS) was utilized to obtain potential biomarkers of coronary heart disease (CHD) patients and investigate the ZHENG types differentiation in CHD patients. The plasma samples of 20 CHD patients with phlegm syndrome, 20 CHD patients with blood-stasis syndrome, and 16 healthy volunteers were collected in the study. 26 potential biomarkers were identified in the plasma of CHD patients and 19 differential metabolites contributed to the discrimination of phlegm syndrome and blood-stasis syndrome in CHD patients (VIP > 1.5; P < 0.05) which mainly involved purine metabolism, pyrimidine metabolism, amino acid metabolism, steroid biosynthesis, and arachidonic acid metabolism. This study demonstrated that metabonomics approach based on LC-MS was useful for studying pathologic changes of CHD patients and interpreting the differentiation of ZHENG types (phlegm and blood-stasis syndrome) in traditional Chinese medicine (TCM).
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影响因子：
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作者：
Matsumoto, Chinami;Kojima, Tetsuko;Ogawa, Kazuo;Kamegai, Satoshi;Oyama, Takuya;Shibagaki, Yukari;Kawasaki, Tetsuo;Fujinaga, Hiroshi;Takahashi, Kozo;Hikiami, Hiroaki;Goto, Hirozo;Kiga, Chizuru;Koizumi, Keiichi;Sakurai, Hiroaki;Muramoto, Hiroshi;Shimada, Yutaka;Yamamoto, Masahiro;Terasawa, Katsutoshi;Takeda, Shuichi;Saiki, Ikuo
通讯作者：
Saiki, Ikuo
通过血浆代谢组学分析鉴定不稳定型心绞痛的生物标志物
影响因子：
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作者：
Sun, Meng;Gao, Xueqin;Yu, Bo
通讯作者：
Yu, Bo
超高效液相色谱/四极杆飞行时间质谱结合模式识别方法和代谢途径分析血龙树脂对心肌缺血大鼠的代谢组学研究
DOI：
10.1155/2013/438680
发表时间：
2013
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
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作者：
Qi Y;Gu H;Song Y;Dong X;Liu A;Lou Z;Fan G;Chai Y
通讯作者：
Chai Y
影响因子：
1.8
作者：
Nicholson, JK;Lindon, JC;Holmes, E
通讯作者：
Holmes, E
影响因子：
13.2
作者：
Athyros, VG;Elisaf, M;Mikhailidis, DP
通讯作者：
Mikhailidis, DP