Spatiotemporal regulation of store-operated calcium entry in cancer metastasis.
Spatiotemporal regulation of store-operated calcium entry in cancer metastasis.
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DOI：
10.1042/bst20210307
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发表时间：
2021-12-17
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
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作者：
储存操纵的钙 (Ca2+) 进入 (SOCE) 是细胞用来补充耗尽的 Ca2+ 储存的 Ca2+ 进入机制。转移性癌症中已有 SOCE 失调的报道。人们认为 SOCE 通过重塑肌动蛋白细胞骨架和细胞粘附动力学来促进迁移和侵袭。最近的证据表明 SOCE 对于细胞内 Ca2+ 信号的空间和时间编码至关重要。在这篇综述中，我们批判性地研究了 SOCE 信号传导的时空控制及其对 SOCE 下游信号传导事件的特异性和鲁棒性的影响，重点关注癌细胞迁移、侵袭和转移过程中的时空 SOCE 信号传导。我们进一步讨论了我们目前对癌症转移中 SOCE 的理解的局限性以及克服这种局限性的潜在方法。
The store-operated calcium (Ca2+) entry (SOCE) is the Ca2+ entry mechanism used by cells to replenish depleted Ca2+ store. The dysregulation of SOCE has been reported in metastatic cancer. It is believed that SOCE promotes migration and invasion by remodeling the actin cytoskeleton and cell adhesion dynamics. There is recent evidence supporting that SOCE is critical for the spatial and the temporal coding of Ca2+ signals in the cell. In this review, we critically examined the spatiotemporal control of SOCE signaling and its implication in the specificity and robustness of signaling events downstream of SOCE, with a focus on the spatiotemporal SOCE signaling during cancer cell migration, invasion and metastasis. We further discuss the limitation of our current understanding of SOCE in cancer metastasis and potential approaches to overcome such limitation.
DOI：
10.1016/j.cub.2009.08.051
发表时间：
2009-11-03
期刊：
Current biology : CB
影响因子：
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作者：
Mancarella S;Wang Y;Gill DL
通讯作者：
Gill DL