Calcium signals: STIM dynamics mediate spatially unique oscillations.

Calcium signals: STIM dynamics mediate spatially unique oscillations.
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DOI:
10.1016/j.cub.2009.08.051
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发表时间:
2009-11-03
期刊:
Current biology : CB
影响因子:
--
通讯作者:
Gill DL
Gill DL
中科院分区:
其他
文献类型:
--
作者:
Mancarella S;Wang Y;Gill DL

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受体诱导的钙振荡提供“数字化”信号,精确激活下游靶标。新的研究表明,STIM蛋白-内质网钙水平的传感器-在振荡过程中周期性移位,瞬时耦合激活细胞表面钙进入通道,产生空间上独特的信号,选择性地触发即刻-早期基因表达。
Receptor-induced Ca2+ oscillations provide ‘digitized’ signals that confer precise activation of downstream targets. New studies reveal that STIM proteins — sensors of endoplasmic reticulum Ca2+ levels — cyclically translocate during oscillations, transiently coupling to activate cell-surface Ca2+ entry channels, resulting in a spatially unique signal that selectively triggers immediate-early gene expression.
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