Maternal methadone dosing schedule and fetal neurobehaviour.
Maternal methadone dosing schedule and fetal neurobehaviour.
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DOI：
10.1080/14767050802452291
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发表时间：
2009-01
期刊：
影响因子：
--
通讯作者：
Kivlighan KT
中科院分区：
文献类型：
--
作者：
Jansson LM;Dipietro JA;Velez M;Elko A;Knauer H;Kivlighan KT
每日美沙酮维持是怀孕期间阿片类药物依赖的标准护理。先前的研究表明，单剂量母亲美沙酮管理显着抑制胎儿的神经行为。本研究的目的是确定分次给药对胎仔神经行为的影响是否小于单次给药。四十美沙酮维持妇女进行了评价，在峰值和谷值的母亲美沙酮水平上的单次和分裂剂量的时间表。在平衡研究设计中，在妊娠36周和37周进行监测。胎儿测量包括心率、变异性、加速度、运动活动和胎儿运动-心率耦合（FM-FHR）。母亲测量指标包括心动周期、变异性、皮肤电导、呼吸和迷走神经张力。重复测量方差分析用于评价分次和单次给药方案之间的受试者内变化。无论给药方案如何，母体美沙酮给药均抑制了所有胎儿神经行为参数。单次美沙酮给药与分次美沙酮给药期间，峰值时的胎儿参数显著较低。与单次给药相比，在分次给药期间，FM-FHR偶联从谷值到峰值的抑制程度更低。母体生理参数通常不受给药条件的影响。与单次给药的胎儿相比，分次给药的胎儿从母体美沙酮水平的谷值到峰值表现出较少的神经行为抑制。分次给药可能对维持美沙酮的孕妇有益。
Daily methadone maintenance is the standard of care for opiate dependency during pregnancy. Previous research has indicated that single-dose maternal methadone administration significantly suppresses fetal neurobehaviors. The purpose of this study was to determine if split-dosing would have less impact on fetal neurobehavior than single-dose administration. Forty methadone-maintained women were evaluated at peak and trough maternal methadone levels on single- and split-dosing schedules. Monitoring sessions occurred at 36 and 37 weeks gestation in a counterbalanced study design. Fetal measures included heart rate, variability, accelerations, motor activity and fetal movement-heart rate coupling (FM-FHR). Maternal measures included heart period, variability, skin conductance, respiration and vagal tone. Repeated measure analysis of variance was used to evaluate within-subject changes between split- and single-dosing regimens. All fetal neurobehavioral parameters were suppressed by maternal methadone administration, regardless of dosing regimen. Fetal parameters at peak were significantly lower during single vs. split methadone administration. FM-FHR coupling was less suppressed from trough to peak during split-dosing vs. single-dosing. Maternal physiologic parameters were generally unaffected by dosing condition. Split- dosed fetuses displayed less neurobehavioral suppression from trough to peak maternal methadone levels as compared to single-dosed fetuses. Split-dosing may be beneficial for methadone-maintained pregnant women.
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影响因子：
2.8
作者：
FINNEGAN, LP
通讯作者：
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影响因子：
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作者：
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DOI：
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发表时间：
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影响因子：
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