The behavioral deficit observed following noncontingent shock in spinalized rats is prevented by the protein synthesis inhibitor cycloheximide.
The behavioral deficit observed following noncontingent shock in spinalized rats is prevented by the protein synthesis inhibitor cycloheximide.
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蛋白质合成抑制剂放线菌酮可防止脊髓化大鼠非偶然休克后观察到的行为缺陷。
DOI：
10.1037/0735-7044.118.3.653
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Grau,JamesW
中科院分区：
文献类型：
--
作者：
Patton,BrianneC;Hook,MichelleA;Ferguson,AdamR;Crown,EricD;Grau,JamesW
Spinalized rats that receive shock when 1 hind limb is extended (contingent shock) exhibit an increase in flexion duration, a simple form of instrumental learning. Rats that receive shock independent of leg position (noncontingent shock) do not exhibit an increase in flexion duration and fail to learn when tested with contingent shock 24 hr later. It appears that noncontingent shock induces an intraspinal modification that inhibits the capacity to learn. The authors propose that the mechanisms that underlie this effect depend on de novo protein synthesis. To evaluate this hypothesis, the authors gave spinalized rats the protein synthesis inhibitor Cycloheximide (CXM) or saline intrathecally prior to, or immediately after, noncontingent shock exposure. Twenty-four hours later, rats were tested with contingent shock. Rats that received the vehicle and noncontingent shock failed to learn. CXM-treated shocked rats learned normally, suggesting that the learning deficit depends on protein synthesis within the spinal cord.(PsycINFO Database Record (c) 2016 APA, all rights reserved)
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影响因子：
1.9
作者：
J. Grau;Douglas G. Barstow;R. Joynes
通讯作者：
J. Grau;Douglas G. Barstow;R. Joynes
影响因子：
3.8
作者：
CHOPIN, SF;BUERGER, AA
通讯作者：
BUERGER, AA
脊髓背角的有害刺激诱导的可塑性：使用福尔马林测试获得的机制的证据和见解
DOI：
10.1007/978-1-4615-1437-4_7
发表时间：
2001
期刊：
The Journal of Pain
影响因子：
--
作者：
T. Coderre
通讯作者：
T. Coderre
在大鼠中，通过脊髓给予GABAA可以防止炎症诱导的兴奋性氨基酸的释放，但不能通过GABAB受体拮抗剂来防止。
DOI：
--
发表时间：
1994
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Sluka,KA;Willis,WD;Westlund,KN
通讯作者：
Westlund,KN
DOI：
10.1098/rspb.1962.0061
发表时间：
1962
期刊：
Proceedings of the Royal Society of London. Series B. Biological Sciences
影响因子：
--
作者：
G. Horridge
通讯作者：
G. Horridge