Noxious Stimulus-Induced Plasticity in Spinal Cord Dorsal Horn: Evidence and Insights on Mechanisms Obtained Using the Formalin Test
Noxious Stimulus-Induced Plasticity in Spinal Cord Dorsal Horn: Evidence and Insights on Mechanisms Obtained Using the Formalin Test
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脊髓背角的有害刺激诱导的可塑性：使用福尔马林测试获得的机制的证据和见解
DOI：
10.1007/978-1-4615-1437-4_7
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
T. Coderre
中科院分区：
文献类型：
--
作者：
T. Coderre
After tissue or nerve injury, animals develop an increased sensitivity to noxious and non-noxious cutaneous stimuli, paralleling the development of hyperalgesia and allodynia in humans. While these changes depend partly on sensitization in peripheral tissues, there is also evidence that the increased sensitivity depends on sensitization within the central nervous system (CNS). Central sensitization after tissue or neural injury has been defined as a change in excitability of CNS neurons which is triggered by and outlasts nociceptive afferent inputs (Woolf and Chong, 1993). There is evidence indicating that persistent nociceptive responses to chemical stimulation with formalin depend on a sensitization of spinal cord neurons, which occurs in the early period after injury. Indeed, the formalin test has been used now for 10 years as an animal model of noxious stimulus-induced plasticity. In this paper, I will debate the evidence supporting the view that the formalin test reflects a sensitization of spinal cord neurons. Additionally, I will discuss some of the potential mediators that lead to the development of formalin injury-induced plasticity in spinal cord.
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影响因子：
56.9
作者：
KIM, D;CLAPHAM, DE
通讯作者：
CLAPHAM, DE
影响因子：
9.8
作者：
GOTO, T;MAROTA, JJA;CROSBY, G
通讯作者：
CROSBY, G
一氧化氮：第一种新型神经递质。
DOI：
10.1126/science.1353273
发表时间：
1992
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Snyder,SH
通讯作者：
Snyder,SH
影响因子：
2.9
作者：
Hossaini, Mehdi;French, Pim J.;Holstege, Jan C.
通讯作者：
Holstege, Jan C.
早期伤害性事件影响皮下福尔马林的强直反应的时间分布，但不影响其强度：瑞芬太尼的作用。
DOI：
--
发表时间：
1997
期刊：
The Journal of pharmacology and experimental therapeutics.
影响因子：
--
作者：
Taylor,BK;Peterson,MA;Basbaum,AI
通讯作者：
Basbaum,AI