Myocardial effects of VDR activators in renal failure.
Myocardial effects of VDR activators in renal failure.
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DOI：
10.1016/j.jsbmb.2010.03.026
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发表时间：
2010-07
影响因子：
4.1
通讯作者：
Slatopolsky, Eduardo
中科院分区：
文献类型：
--
作者：
Mizobuchi, Masahide;Nakamura, Hironori;Tokumoto, Masanori;Finch, Jane;Morrissey, Jeremiah;Liapis, Helen;Slatopolsky, Eduardo
心血管并发症是慢性肾脏病(CKD)患者的主要死亡原因。糖尿病、吸烟、衰老和高血压等传统原因并不能完全解释这些患者心血管疾病的高发病率。肾素-血管紧张素-醛固酮系统(RAAS)调节细胞外容量的稳态，有助于血压的稳定。该系统的过度活动参与了心肾疾病的病理生理学过程。新的证据表明，维生素D受体激活剂(VDRAs)对RAAS有抑制作用，但VDRAs也有抗炎和抗纤维化的作用。我们已经证明，维拉帕米可通过上调VDR、降低心肌增殖细胞核抗原和降低心肌氧化应激来改善尿毒症大鼠的左室肥厚(LVH)。因此，骨钙素可能通过上调VDR来抑制LVH、心肌及血管周围纤维化和心肌动脉血管厚度的进展。帕利卡西醇可能被证明对慢性肾脏病患者的心脏疾病及其转归有实质性的有益影响。有必要对CKD患者进行前瞻性随机研究来证实这些结果。
Cardiovascular complications are the leading cause of death in patients with chronic kidney disease (CKD). Traditional causes such as diabetes, smoking, aging and hypertension do not fully explain the high rate of morbidity from cardiovascular disease seen in these patients. The renin-angiotensin-aldosterone system (RAAS) regulates extracellular volume homeostasis, which contributes to blood pressure stability. Overactivity of this system is involved in the pathophysiology of cardio-renal disease. New evidence suggests that vitamin D receptor activators (VDRAs) have a suppressive effect on the RAAS; However, VDRAs also have anti-inflammatory and anti-fibrotic effects. We have demonstrated that paricalcitol, a VDRA, ameliorates left ventricular hypertrophy (LVH) in uremic rats by up-regulating the VDR, decreasing myocardial PCNA and also decreasing myocardial oxidative stress. Thus, paricalcitol can suppress the progression of LVH, myocardial and perivascular fibrosis and myocardial arterial vessel thickness presumably by up regulating the VDR. Paricalcitol may prove to have a substantial beneficial effect on cardiac disease and its outcome in patients with CKD. Prospective randomized studies in CKD patients are necessary to confirm these results.
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DOI：
10.1152/ajpregu.00517.2002
发表时间：
2003-07-01
影响因子：
2.8
作者：
Kong, J;Li, YC
通讯作者：
Li, YC
影响因子：
13.6
作者：
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影响因子：
19.6
作者：
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Zager, P. G.