Unfavorable impact of cancer cachexia on activity of daily living and need for inpatient care in elderly patients with advanced non-small-cell lung cancer in Japan: a prospective longitudinal observational study.
Unfavorable impact of cancer cachexia on activity of daily living and need for inpatient care in elderly patients with advanced non-small-cell lung cancer in Japan: a prospective longitudinal observational study.
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DOI：
10.1186/s12885-017-3795-2
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发表时间：
2017-11-28
期刊：
影响因子：
3.8
通讯作者：
Takahashi T
中科院分区：
文献类型：
--
作者：
Naito T;Okayama T;Aoyama T;Ohashi T;Masuda Y;Kimura M;Shiozaki H;Murakami H;Kenmotsu H;Taira T;Ono A;Wakuda K;Imai H;Oyakawa T;Ishii T;Omori S;Nakashima K;Endo M;Omae K;Mori K;Yamamoto N;Tanuma A;Takahashi T
老年患者的癌症恶病质可能会严重影响身体功能和医疗依赖性。本研究的目的是评估恶病质对接受化疗的老年晚期非小细胞肺癌（NSCLC）患者的日常生活活动（ADL）、住院时间和住院医疗费用的影响。2013年1月至2014年11月，前瞻性纳入30例年龄≥70岁的晚期NSCLC （III-IV期）患者，计划接受一线化疗。采用Barthel指数评价ADL。无残疾生存时间（DFS）计算为研究开始日期到残疾事件发生日期之间的时间，其定义为Barthel指数比基线下降10点。计算住院时间与住院医疗费用（¥，日元）的平均累积函数。该研究患者包括11名女性和19名男性，中位年龄为74岁（范围70-82岁）。19例（63%）患者被诊断为恶病质。恶病质患者DFS较短（7.5个月vs. 17.1个月，p < 0.05）。在研究开始的第一年，恶病质患者的累计住院时间更长（80.7 vs. 38.5天/人，p < 0.05），非计划住院次数或住院次数更多（4.2 vs. 1.7次/人，p < 0.05），住院医疗费用更高（3.5 vs. 210万/人，p < 0.05）。与无恶病质的老年NSCLC患者相比，有恶病质的老年NSCLC患者在接受化疗时出现更高的致残风险、住院时间延长和住院医疗费用。我们的研究结果可能表明，有可能需要早期干预，以减少恶病质的进展或发展，改善功能预后，并减少这一人群的医疗资源负担。试验注册号：UMIN000009768。注册名称：UMIN（大学医院医疗信息网络）。注册日期：2013年1月14日。首位受试者入组日期：2013年1月23日。
Cancer cachexia in elderly patients may substantially impact physical function and medical dependency. The aim of this study was to estimate the impact of cachexia on activity of daily living (ADL), length of hospital stay, and inpatient medical costs among elderly patients with advanced non-small-cell lung cancer (NSCLC) receiving chemotherapy. Thirty patients aged ≥70 years with advanced NSCLC (stage III-IV) scheduled to receive first-line chemotherapy were prospectively enrolled between January 2013 and November 2014. ADL was assessed using the Barthel index. The disability-free survival time (DFS) was calculated as the time between the date of study entry and the date of onset of a disabling event, which was defined as a 10-point decrease in the Barthel index from that at baseline. The mean cumulative function of the length of hospital stay and inpatient medical costs (¥, Japanese yen) was calculated. The study patients comprised 11 women and 19 men, with a median age of 74 (range, 70–82) years. Cachexia was diagnosed in 19 (63%) patients. Cachectic patients had a shorter DFS (7.5 vs. 17.1 months, p < 0.05). During the first year from study entry, cachectic patients had longer cumulative lengths of hospital stay (80.7 vs. 38.5 days/person, p < 0.05), more frequent unplanned hospital visits or hospitalizations (4.2 vs. 1.7 times/person, p < 0.05), and higher inpatient medical costs (¥3.5 vs. ¥2.1 million/person, p < 0.05) than non-cachectic patients. Elderly NSCLC patients with cachexia showed higher risks for disability, prolonged hospitalizations, and higher inpatient medical costs while receiving chemotherapy than patients without cachexia. Our results might indicate that there is a potential need for an early intervention to minimize progression to or development of cachexia, improve functional prognosis, and reduce healthcare resource burden in this population. Trial registration number: UMIN000009768. Name of registry: UMIN (University hospital Medical Information Network). Date of registration: 14 January 2013. Date of enrolment of the first participant to the trial: 23 January 2013.
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影响因子：
6.3
作者：
Arends, Jann;Bachmann, Patrick;Preiser, Jean-Charles
通讯作者：
Preiser, Jean-Charles
影响因子：
3.1
作者：
Kimura, Madoka;Naito, Tateaki;Yamamoto, Nobuyuki
通讯作者：
Yamamoto, Nobuyuki
DOI：
10.1007/s00520-016-3156-8
发表时间：
2016-08
期刊：
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
影响因子：
--
作者：
Takayama K;Atagi S;Imamura F;Tanaka H;Minato K;Harada T;Katakami N;Yokoyama T;Yoshimori K;Takiguchi Y;Hataji O;Takeda Y;Aoe K;Kim YH;Yokota S;Tabeta H;Tomii K;Ohashi Y;Eguchi K;Watanabe K
通讯作者：
Watanabe K
影响因子：
4.8
作者：
Flumpbries, Karin H.;Pu, Aihua;Pilote, Louise
通讯作者：
Pilote, Louise
影响因子：
28.4
作者：
Global Burden of Disease Cancer Collaboration;Fitzmaurice C;Dicker D;Pain A;Hamavid H;Moradi-Lakeh M;MacIntyre MF;Allen C;Hansen G;Woodbrook R;Wolfe C;Hamadeh RR;Moore A;Werdecker A;Gessner BD;Te Ao B;McMahon B;Karimkhani C;Yu C;Cooke GS;Schwebel DC;Carpenter DO;Pereira DM;Nash D;Kazi DS;De Leo D;Plass D;Ukwaja KN;Thurston GD;Yun Jin K;Simard EP;Mills E;Park EK;Catalá-López F;deVeber G;Gotay C;Khan G;Hosgood HD 3rd;Santos IS;Leasher JL;Singh J;Leigh J;Jonas JB;Sanabria J;Beardsley J;Jacobsen KH;Takahashi K;Franklin RC;Ronfani L;Montico M;Naldi L;Tonelli M;Geleijnse J;Petzold M;Shrime MG;Younis M;Yonemoto N;Breitborde N;Yip P;Pourmalek F;Lotufo PA;Esteghamati A;Hankey GJ;Ali R;Lunevicius R;Malekzadeh R;Dellavalle R;Weintraub R;Lucas R;Hay R;Rojas-Rueda D;Westerman R;Sepanlou SG;Nolte S;Patten S;Weichenthal S;Abera SF;Fereshtehnejad SM;Shiue I;Driscoll T;Vasankari T;Alsharif U;Rahimi-Movaghar V;Vlassov VV;Marcenes WS;Mekonnen W;Melaku YA;Yano Y;Artaman A;Campos I;MacLachlan J;Mueller U;Kim D;Trillini M;Eshrati B;Williams HC;Shibuya K;Dandona R;Murthy K;Cowie B;Amare AT;Antonio CA;Castañeda-Orjuela C;van Gool CH;Violante F;Oh IH;Deribe K;Soreide K;Knibbs L;Kereselidze M;Green M;Cardenas R;Roy N;Tillmann T;Li Y;Krueger H;Monasta L;Dey S;Sheikhbahaei S;Hafezi-Nejad N;Kumar GA;Sreeramareddy CT;Dandona L;Wang H;Vollset SE;Mokdad A;Salomon JA;Lozano R;Vos T;Forouzanfar M;Lopez A;Murray C;Naghavi M
通讯作者：
Naghavi M