Growth hormone and aging: a challenging controversy.
Growth hormone and aging: a challenging controversy.
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生长激素和衰老：一个具有挑战性的争议。
DOI：
10.2147/cia.s3697
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发表时间：
2008
影响因子：
3.6
通讯作者：
Bartke A
中科院分区：
文献类型：
--
作者：
Bartke A
虽然高龄或衰老症状不在生长激素（GH）治疗的批准适应症之列，但重组人GH（rhGH）和各种GH相关产品被积极推广为抗衰老疗法。在内分泌正常的老年受试者中进行的rhGH治疗效果的良好对照研究报告了身体组成的一些改善和一些不良副作用，与GH缺乏症患者中GH治疗的主要获益形成鲜明对比。越来越多的证据表明GH与癌症有关，GH耐药和GH缺陷小鼠的寿命显著延长，这加剧了围绕GH治疗老年患者的潜在效用的争议。影响从蠕虫到哺乳动物等生物衰老的细胞信号机制的保守性表明，在突变小鼠中获得的至少一些结果适用于人类。我们认为，生长激素在促进生长，性成熟和繁殖力的正常生理功能涉及显着的成本方面的老化和预期寿命。在衰老过程中生长激素水平的自然下降可能有助于身体组成和活力的伴随变化，但也可能提供重要的保护，免受癌症和其他与年龄相关的疾病。
Although advanced age or symptoms of aging are not among approved indications for growth hormone (GH) therapy, recombinant human GH (rhGH) and various GH-related products are aggressively promoted as anti-aging therapies. Well-controlled studies of the effects of rhGH treatment in endocrinologically normal elderly subjects report some improvements in body composition and a number of undesirable side effects in sharp contrast to major benefits of GH therapy in patients with GH deficiency. Controversies surrounding the potential utility of GH in treatment of a geriatric patient are fueled by increasing evidence linking GH and cancer and by remarkably increased lifespan of GH-resistant and GH-deficient mice. Conservation of cellular signaling mechanisms that influence aging in organisms ranging from worms to mammals suggests that at least some of the results obtained in mutant mice are applicable to the human. We suggest that the normal, physiological functions of GH in promoting growth, sexual maturation and fecundity involve significant costs in terms of aging and life expectancy. Natural decline in GH levels during aging likely contributes to concomitant alterations in body composition and vigor but also may be offering important protection from cancer and other age-associated diseases.
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影响因子：
4.8
作者：
Coschigano, KT;Holland, AN;Kopchick, JJ
通讯作者：
Kopchick, JJ
DOI：
10.1093/gerona/61.6.562
发表时间：
2006-06-01
影响因子：
5.1
作者：
Bonkowski, MS;Pamenter, RW;Bartke, A
通讯作者：
Bartke, A
影响因子：
4.8
作者：
Chandrashekar, V;Bartke, A;Kopchick, JJ
通讯作者：
Kopchick, JJ
影响因子：
2.4
作者：
Greer, Kimberly A.;Canterberry, Sarah C.;Murphy, Keith E.
通讯作者：
Murphy, Keith E.
DOI：
10.2460/javma.2003.223.93
发表时间：
2003-07-01
期刊：
JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
影响因子：
--
作者：
Brosnahan, MM;Paradis, MR
通讯作者：
Paradis, MR