INSIG2 SNPs associated with obesity and glucose homeostasis traits in Hispanics: the IRAS Family Study.
INSIG2 SNPs associated with obesity and glucose homeostasis traits in Hispanics: the IRAS Family Study.
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DOI：
10.1038/oby.2009.94
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发表时间：
2009-08
期刊：
影响因子：
6.9
通讯作者：
Bowden, Donald W.
中科院分区：
文献类型：
--
作者：
Talbert, Matthew E.;Langefeld, Carl D.;Ziegler, Julie T.;Haffner, Steven M.;Norris, Jill M.;Bowden, Donald W.
Herbert 及其同事进行的全基因组关联研究发现，INSIG2 单核苷酸多态性 (SNP) rs7566605 有助于不同种族群体中 BMI 的增加。本研究试图通过测试 INSIG2 的 SNP 是否影响胰岛素抵抗动脉粥样硬化家族研究 (IRASFS) 西班牙裔的肥胖数量或葡萄糖稳态特征来进一步阐明。使用标记 SNP 方法，对 1425 名 IRASFS 西班牙裔人的 rs7566605 和另外 31 个 SNP 进行了基因分型。测试了 SNP 与六种肥胖指标的关联：BMI、腰围 (WAIST)、腰臀比 (WHR)、皮下脂肪组织 (SAT)、内脏脂肪组织 (VAT) 和 VAT 与 SAT 比率 (VSR)。还测试了 SNP 与空腹血糖 (GFAST)、空腹胰岛素 (FINS) 以及从频繁采样的静脉内葡萄糖耐量试验中获得的三个指标的关联：胰岛素敏感性 (SI)、急性胰岛素反应 (AIR) 和处置指数 (DI)。观察到最显着的关联与直接 CT 测量的肥胖表型，包括 VAT、SAT 和 VSR（rs17586756、rs17047718、rs17047731、rs9308762、rs12623648 和 rs17586756、rs17047718、rs17047731、rs9308762、rs12623648 和rs11673900）。所有葡萄糖稳态特征均观察到多个 SNP 关联（rs17047718、rs17047731、rs2161829、rs10490625、rs889904 和 rs12623648 的 P 值范围为 0.001 至 0.031）。使用 BMI 作为评估葡萄糖稳态特征的协变量略微降低了它们的关联性。然而，经过多重比较调整后，与肥胖和葡萄糖稳态表型的关联并不显着。多重比较调整后的趋势关联仍然表明 INSIG2 遗传变异在肥胖中的作用，但这些结果需要验证。
The genome-wide association study by Herbert and colleagues identified the INSIG2 single nucleotide polymorphism (SNP) rs7566605 as contributing to increased BMI in ethnically distinct cohorts. The present study sought to further clarify by testing whether SNPs of INSIG2 influenced quantitative adiposity or glucose homeostasis traits in Hispanics of the Insulin Resistance Atherosclerosis Family Study (IRASFS). Using a tagging SNP approach, rs7566605 and 31 additional SNPs were genotyped in 1425 IRASFS Hispanics. SNPs were tested for association with six adiposity measures: BMI, waist circumference (WAIST), waist to hip ratio (WHR), subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and VAT to SAT ratio (VSR). SNPs were also tested for association with fasting glucose (GFAST), fasting insulin (FINS), and three measures obtained from the frequently sampled intravenous glucose tolerance test: insulin sensitivity (SI), acute insulin response (AIR), and disposition index (DI). Most prominent association was observed with direct CT-measured adiposity phenotypes, including VAT, SAT, and VSR (P-values range from 0.007 to 0.044 for rs17586756, rs17047718, rs17047731, rs9308762, rs12623648, and rs11673900). Multiple SNP associations were observed with all glucose homeostasis traits (P-values range from 0.001 to 0.031 for rs17047718, rs17047731, rs2161829, rs10490625, rs889904, and rs12623648). Using BMI as a covariate in evaluation of glucose homeostasis traits slightly reduced their association. However, association with adiposity and glucose homeostasis phenotypes is not significant following multiple comparisons adjustment. Trending association after multiple comparisons adjustment remains suggestive of a role for genetic variation of INSIG2 in obesity, but these results require validation.
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在研究中，在Indig2和PFKP中的常见变体与肥胖症中基于全基因组的相关性的不复制在18,014个DANES的研究中。
影响因子：
3.7
作者：
Andreasen CH;Mogensen MS;Borch-Johnsen K;Sandbaek A;Lauritzen T;Sørensen TI;Hansen L;Almind K;Jørgensen T;Pedersen O;Hansen T
通讯作者：
Hansen T
影响因子：
5.4
作者：
Boston, Ray C;Stefanovski, Darko;Bergman, Richard N
通讯作者：
Bergman, Richard N
影响因子：
8.2
作者：
Krapivner, S.;Chernogubova, E.;van't Hooft, F. M.
通讯作者：
van't Hooft, F. M.
DOI：
10.1073/pnas.021506298
发表时间：
2001-01-16
影响因子：
11.1
作者：
Buetow, KH;Edmonson, M;Braun, A
通讯作者：
Braun, A
影响因子：
2.1
作者：
Blangero, J;Williams, JT;Almasy, L
通讯作者：
Almasy, L