Neovascularization: The Main Mechanism of MSCs in Ischemic Heart Disease Therapy.
Neovascularization: The Main Mechanism of MSCs in Ischemic Heart Disease Therapy.
复制标题
新生血管形成：间充质干细胞治疗缺血性心脏病的主要机制
DOI：
10.3389/fcvm.2021.633300
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发表时间：
2021
影响因子：
3.6
通讯作者：
Chen K
中科院分区：
文献类型：
--
作者：
Shi W;Xin Q;Yuan R;Yuan Y;Cong W;Chen K
大量临床和临床前研究表明，心肌梗死（MI）后的间充质干细胞（MSC）移植可有效限制梗塞面积。然而，与 MSC 移植治疗中的这种活性相关的主要机制仍不清楚。血液供应是心肌组织生存的根本，而高效的血管网络的形成是血运的前提。间充质干细胞的旁分泌功能贯穿于整个新生血管形成过程，包括间充质干细胞的动员、迁移、归巢、粘附和保留，通过现有的内皮细胞（EC）和内皮祖细胞（EPC）调节血管生成和血管发生。此外，MSCs具有分化为多种细胞谱系的能力，可以被动员并迁移到缺血组织，在一定程度上分化为ECs、周细胞和平滑肌细胞，这些都是血管的必要组成部分。 MSC 的这些特征支持这些细胞通过血管生成和血管发生改善缺血心肌的观点。在这篇综述中，讨论了最近的临床和临床前研究的结果，以说明缺血性心脏病中新生血管形成的过程和机制。
Mesenchymal stem cell (MSC) transplantation after myocardial infarction (MI) has been shown to effectively limit the infarct area in numerous clinical and preclinical studies. However, the primary mechanism associated with this activity in MSC transplantation therapy remains unclear. Blood supply is fundamental for the survival of myocardial tissue, and the formation of an efficient vascular network is a prerequisite for blood flow. The paracrine function of MSCs, which is throughout the neovascularization process, including MSC mobilization, migration, homing, adhesion and retention, regulates angiogenesis and vasculogenesis through existing endothelial cells (ECs) and endothelial progenitor cells (EPCs). Additionally, MSCs have the ability to differentiate into multiple cell lineages and can be mobilized and migrate to ischemic tissue to differentiate into ECs, pericytes and smooth muscle cells in some degree, which are necessary components of blood vessels. These characteristics of MSCs support the view that these cells improve ischemic myocardium through angiogenesis and vasculogenesis. In this review, the results of recent clinical and preclinical studies are discussed to illustrate the processes and mechanisms of neovascularization in ischemic heart disease.
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影响因子：
56.9
作者：
Asahara, T;Murohara, T;Isner, JM
通讯作者：
Isner, JM
影响因子：
3.7
作者：
Cai, Anping;Zheng, Dongdan;Mai, Weiyi
通讯作者：
Mai, Weiyi
影响因子：
20.1
作者：
Cogle CR;Wise E;Meacham AM;Zierold C;Traverse JH;Henry TD;Perin EC;Willerson JT;Ellis SG;Carlson M;Zhao DX;Bolli R;Cooke JP;Anwaruddin S;Bhatnagar A;da Graca Cabreira-Hansen M;Grant MB;Lai D;Moyé L;Ebert RF;Olson RE;Sayre SL;Schulman IH;Bosse RC;Scott EW;Simari RD;Pepine CJ;Taylor DA;Cardiovascular Cell Therapy Research Network (CCTRN)
通讯作者：
Cardiovascular Cell Therapy Research Network (CCTRN)
DOI：
10.1161/circinterventions.113.001009
发表时间：
2014-04-01
影响因子：
5.6
作者：
de Jong, Renate;Houtgraaf, Jaco H.;Duckers, Henricus J.
通讯作者：
Duckers, Henricus J.
影响因子：
4.5
作者：
Chullikana, Anoop;Sen Majumdar, Anish;Gupta, Pawan Kumar
通讯作者：
Gupta, Pawan Kumar