Spatiotemporal integration of tactile information in human somatosensory cortex.
Spatiotemporal integration of tactile information in human somatosensory cortex.
复制标题
人体感皮质中触觉信息的时空整合。
DOI：
10.1186/1471-2202-8-21
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发表时间：
2007-03-14
期刊：
影响因子：
2.4
通讯作者：
Nagarajan, Srikantan S.
中科院分区：
文献类型：
--
作者：
Zhu, Zhao;Disbrow, Elizabeth A.;Zumer, Johanna M.;McGonigle, David J.;Nagarajan, Srikantan S.
我们的目标是研究触觉信息的时空整合的手表示人类初级躯体感觉皮层（前顶叶躯体感觉区3b和1），次级躯体感觉皮层（S2），顶叶腹侧区（PV），使用高分辨率全头脑磁图（MEG）。为了研究代表重叠和适应双边体感皮层，我们使用了一个古怪的范式表征的食指（D2;偏差刺激）作为一个功能的标准刺激的位置在右手和左手的科目。我们发现，在标准刺激的背景下，与刺激间间隔（ISI）为0.33秒的偏差刺激的反应显着和双边衰减相比，偏差刺激单独在S2/PV，但不是在前顶叶皮层。这种衰减取决于偏离和标准刺激之间的距离：当标准刺激紧邻偏离时（分别为D3和D2），衰减更大，非相邻手指（D4和相对的D2）的衰减减小。我们还发现，皮肤机械刺激一致引起不仅是一个强大的早期对侧皮层反应，但也在前顶叶皮层同侧反应弱。这种同侧反应比早期对侧反应平均晚10.7 ± 6.1 ms。此外，没有半球的差异，无论是在响应幅度，响应lavidance或oddball反应被发现，独立的利手。我们的研究结果与S2/PV中描述的大感受野和长神经元恢复周期一致，并表明这种时空整合的表达是与该区域相关的复杂功能的基础。同侧的早期反应表明，前顶叶领域也接受触觉输入同侧的手。对手指刺激的反应缺乏半球差异，这支持了人类躯体感觉皮层缺乏任何功能不对称性。
Our goal was to examine the spatiotemporal integration of tactile information in the hand representation of human primary somatosensory cortex (anterior parietal somatosensory areas 3b and 1), secondary somatosensory cortex (S2), and the parietal ventral area (PV), using high-resolution whole-head magnetoencephalography (MEG). To examine representational overlap and adaptation in bilateral somatosensory cortices, we used an oddball paradigm to characterize the representation of the index finger (D2; deviant stimulus) as a function of the location of the standard stimulus in both right- and left-handed subjects. We found that responses to deviant stimuli presented in the context of standard stimuli with an interstimulus interval (ISI) of 0.33s were significantly and bilaterally attenuated compared to deviant stimulation alone in S2/PV, but not in anterior parietal cortex. This attenuation was dependent upon the distance between the deviant and standard stimuli: greater attenuation was found when the standard was immediately adjacent to the deviant (D3 and D2 respectively), with attenuation decreasing for non-adjacent fingers (D4 and opposite D2). We also found that cutaneous mechanical stimulation consistently elicited not only a strong early contralateral cortical response but also a weak ipsilateral response in anterior parietal cortex. This ipsilateral response appeared an average of 10.7 ± 6.1 ms later than the early contralateral response. In addition, no hemispheric differences either in response amplitude, response latencies or oddball responses were found, independent of handedness. Our findings are consistent with the large receptive fields and long neuronal recovery cycles that have been described in S2/PV, and suggest that this expression of spatiotemporal integration underlies the complex functions associated with this region. The early ipsilateral response suggests that anterior parietal fields also receive tactile input from the ipsilateral hand. The lack of a hemispheric difference in responses to digit stimulation supports a lack of any functional asymmetry in human somatosensory cortex.
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