Phylodynamic analysis to inform prevention efforts in mixed HIV epidemics.
Phylodynamic analysis to inform prevention efforts in mixed HIV epidemics.
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DOI：
10.1093/ve/vex014
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发表时间：
2017-07
期刊：
影响因子：
5.3
通讯作者：
Charurat M
中科院分区：
文献类型：
--
作者：
Volz EM;Ndembi N;Nowak R;Kijak GH;Idoko J;Dakum P;Royal W;Baral S;Dybul M;Blattner WA;Charurat M
In HIV epidemics of Sub Saharan Africa, the utility of HIV prevention efforts focused on key populations at higher risk of HIV infection and transmission is unclear. We conducted a phylodynamic analysis of HIV-1 pol sequences from four different risk groups in Abuja, Nigeria to estimate transmission patterns between men who have sex with men (MSM) and a representative sample of newly enrolled treatment naive HIV clients without clearly recorded HIV acquisition risks. We develop a realistic dynamical infectious disease model which was fitted to time-scaled phylogenies for subtypes G and CRF02_AG using a structured-coalescent approach. We compare the infectious disease model and structured coalescent to commonly used genetic clustering methods. We estimate HIV incidence among MSM of 7.9% (95%CI, 7.0–10.4) per susceptible person-year, and the population attributable fraction of HIV transmissions from MSM to reproductive age females to be 9.1% (95%CI, 3.8–18.6), and from the reproductive age women to MSM as 0.2% (95%CI, 0.06–0.3). Applying these parameter estimates to evaluate a test-and-treat HIV strategy that target MSM reduces the total HIV infections averted by half with a 2.5-fold saving. These results suggest the importance of addressing the HIV treatment needs of MSM in addition to cost-effectiveness of specific scale-up of treatment for MSM in the context of the mixed HIV epidemic observed in Nigeria.
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未经治疗的 HIV-1 感染中的 CD4+ 细胞动态：总体比率以及年龄、病毒载量、性别和日历时间的影响。
DOI：
10.1097/qad.0000000000000854
发表时间：
2015-11-28
期刊：
AIDS (London, England)
影响因子：
--
作者：
Cori A;Pickles M;van Sighem A;Gras L;Bezemer D;Reiss P;Fraser C
通讯作者：
Fraser C
影响因子：
10.7
作者：
Kendall, Michelle;Colijn, Caroline
通讯作者：
Colijn, Caroline
DOI：
10.1097/qai.0000000000000439
发表时间：
2015-03-01
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Charurat ME;Emmanuel B;Akolo C;Keshinro B;Nowak RG;Kennedy S;Orazulike I;Ake J;Njoku O;Baral S;Blattner W;TRUST Study Group
通讯作者：
TRUST Study Group
影响因子：
17.1
作者：
Ratmann O;van Sighem A;Bezemer D;Gavryushkina A;Jurriaans S;Wensing A;de Wolf F;Reiss P;Fraser C;ATHENA observational cohort
通讯作者：
ATHENA observational cohort
影响因子：
14.9
作者：
Schultz AK;Zhang M;Bulla I;Leitner T;Korber B;Morgenstern B;Stanke M
通讯作者：
Stanke M