Effects of hyperuricaemia, with the superposition of being overweight and hyperlipidaemia, on the incidence of acute kidney injury following cardiac surgery: a retrospective cohort study.
Effects of hyperuricaemia, with the superposition of being overweight and hyperlipidaemia, on the incidence of acute kidney injury following cardiac surgery: a retrospective cohort study.
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高尿酸血症以及超重和高脂血症的叠加对心脏手术后急性肾损伤发生率的影响：一项回顾性队列研究
DOI：
10.1136/bmjopen-2020-047090
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发表时间：
2022-01-05
期刊：
影响因子：
2.9
通讯作者：
Xu J
中科院分区：
文献类型：
--
作者：
Su Y;Li H;Li Y;Xu X;Shen B;Jiang W;Wang Y;Fang Y;Wang C;Luo Z;Ding X;Teng J;Xu J
急性肾损伤（AKI）是心脏手术的常见并发症。本研究旨在探讨高尿酸血症、超重和高脂血症作为心脏手术（心脏手术相关急性肾损伤（CSA-AKI））患者AKI的危险因素的影响。回顾性观察性研究。大学教学，上海市三级甲等医院。2015年7月至2015年12月在复旦大学中山医院接受心脏手术的患者。我们研究了高尿酸血症、超重和高脂血症对CSA-AKI风险的影响。共有1420名患者入组。高尿酸组AKI发生率为44.4%，低尿酸组为28.5% （p<0.001）。尿酸水平较高的患者同时出现超重和高脂血症的可能性更大（p<0.001）。多因素logistic回归分析显示，高尿酸血症是AKI的独立危险因素（OR=1.237, 95% CI 1.095 ~ 1.885; p=0.009）；单独超重或高脂血症不是独立的危险因素，但超重和高脂血症合并是独立的危险因素（or =1.544, 95% CI 1.059 ~ 2.252; p=0.024）。最终模型中，当高尿酸血症与超重、高脂血症合并时，OR值增加到3.126，Hosmer-Lemeshow检验表明，三个模型均拟合良好（p分别为0.433、0.638和0.597）。超重和高脂血症的结合是一个独立的危险因素，但超重或单独有高脂血症不是。高尿酸血症、超重和高脂血症的合并进一步增加了CSA-AKI的风险。
Acute kidney injury (AKI) is a common complication of cardiac surgery. This study aimed to explore the effects of hyperuricaemia, being overweight and hyperlipidaemia as risk factors for AKI in patients following cardiac surgery (cardiac surgery-associated acute kidney injury (CSA-AKI)). Retrospective observational study. University teaching, grade-A tertiary hospital in Shanghai, China. Patients who underwent cardiac surgery from July 2015 to December 2015 in Zhongshan Hospital, Fudan University. We investigated the effect of hyperuricaemia, in combination with being overweight and hyperlipidaemia, on the risk of CSA-AKI. A total of 1420 patients were enrolled. The AKI incidence in the highest uric acid group was 44.4%, while that in the lowest uric acid group was 28.5% (p<0.001). Patients in the higher uric acid quartiles were more likely to be overweight and hyperlipidaemic at the same time (p<0.001). Multivariate logistic regression analysis showed that hyperuricaemia was an independent risk factor for AKI (OR=1.237, 95% CI 1.095 to 1.885; p=0.009); being overweight or hyperlipidaemia alone was not an independent risk factor, but the combination of being overweight and hyperlipidaemia was (OR=1.544, 95% CI 1.059 to 2.252; p=0.024). In the final model, the OR value increased to 3.126 when hyperuricaemia was combined with being overweight and hyperlipidaemia, and the Hosmer-Lemeshow test showed that all three models fit well (p=0.433, 0.638 and 0.597, respectively). The combination of being overweight and having hyperlipidaemia was an independent risk factor, but being overweight or having hyperlipidaemia alone was not. The combination of hyperuricaemia, being overweight and hyperlipidaemia further increased the risk of CSA-AKI.
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影响因子：
19.6
作者：
Khosla, UM;Zharikov, S;Johnson, RJ
通讯作者：
Johnson, RJ
DOI：
10.1186/cc11454
发表时间：
2013-02-04
期刊：
Critical care (London, England)
影响因子：
--
作者：
Kellum JA;Lameire N;KDIGO AKI Guideline Work Group
通讯作者：
KDIGO AKI Guideline Work Group
影响因子：
5
作者：
Thottam, Gabrielle E.;Krasnokutsky, Svetlana;Pillinger, Michael H.
通讯作者：
Pillinger, Michael H.
影响因子：
13.6
作者：
Henegar, JR;Bigler, SA;Hall, JE
通讯作者：
Hall, JE
DOI：
10.1097/01.asn.0000135971.88164.2c
发表时间：
2004-09-01
影响因子：
13.6
作者：
Chander, PN;Gealekman, O;Goligorsky, MS
通讯作者：
Goligorsky, MS