Generalization in place learning across geometrically different environments is impaired by hippocampal lesions in rats
Generalization in place learning across geometrically different environments is impaired by hippocampal lesions in rats
复制标题
大鼠海马损伤损害了跨几何不同环境的就地学习泛化能力
DOI：
10.1016/j.nlm.2005.03.003
复制
发表时间：
2005
影响因子：
2.7
通讯作者：
E. Save
中科院分区：
文献类型：
--
作者：
L. Tommasi;E. Save
最近的一项研究（Tommasi & Thinus-Blanc，2004）发现，当老鼠被训练在没有食物的情况下搜索隐藏在方形围栏中心的食物时，它们精确地搜索了围栏的中心。在不同形状或大小（矩形，大正方形，等边三角形）的围栏进行转移测试表明，大鼠在几何中心的新环境中搜索。在目前的工作中，一半的大鼠双侧海马损伤，然后在相同的任务中重新训练和重新测试，与接受相同再训练/重新测试方案的假大鼠进行比较。结果表明，损伤大鼠，虽然未受损的再学习本地化的中心的方形外壳，执行比假手术大鼠在不同形状的外壳中的转移测试，这表明相关的作用，海马在几何驱动的地方概括。
A recent study (Tommasi & Thinus-Blanc, 2004) found that when rats trained to search for food hidden in the center of a square-shaped enclosure were tested in the absence of food, they searched precisely in the center of the enclosure. Transfer tests carried out in enclosures differing in shape or size (rectangular-, large square-, and equilateral triangle-shaped) showed that rats searched in the geometric center of the novel environments. In the present work, half of those rats were lesioned bilaterally to the hippocampus and were then re-trained and re-tested in the same task, to be compared to sham rats that received the same retraining/re-test protocol. Results show that lesioned rats, although unimpaired in relearning to localize the center of the square-shaped enclosure, performed considerably worse than sham rats in the transfer tests in the enclosures differing in shape, suggesting a relevant role of the hippocampus in geometry-driven place generalization.
DOI：
10.1523/jneurosci.07-07-01951.1987
发表时间：
1987-07
期刊：
--
影响因子：
--
作者：
R. Muller;J. Kubie
通讯作者：
R. Muller;J. Kubie