Could dantrolene be explored as a repurposed drug to treat COVID-19 patients by restoring intracellular calcium homeostasis?
Could dantrolene be explored as a repurposed drug to treat COVID-19 patients by restoring intracellular calcium homeostasis?
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DOI：
10.26355/eurrev_202010_23247
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发表时间：
2020-10
影响因子：
3.3
通讯作者：
Wei H
中科院分区：
文献类型：
--
作者：
Jiang B;Liang S;Liang G;Wei H
Dantrolene 是 FDA 批准用于治疗恶性高热和肌肉痉挛的药物，已被证明可以抑制严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 介导的宿主细胞毒性。 Ryanodine 受体过度激活和相关的细胞内 Ca2+ 稳态破坏在 SARS-CoV-2 感染和宿主细胞复制中发挥重要作用。 Dantrolene 作为 RyRs 抑制剂，有望改善 SARS-CoV-2 对宿主细胞的这些有害影响。此外，丹曲林还被证明可以抑制缺氧/缺血、线粒体损伤、氧化应激、炎症、自噬和细胞凋亡受损等引起的多种细胞或器官损伤，这些损伤往往是导致COVID-19患者严重和死亡的原因。我们重新认识了丹曲林在治疗 COVID-19 患者并降低其发病率和死亡率方面具有很高的潜力。
Dantrolene, an FDA approved drug to treat malignant hyperthermia and muscle spasm, has been demonstrated to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mediated toxicity of host cells. Ryanodine receptor overactivation and associated disruption of intracellular Ca2+ homeostasis play important roles in SARS-CoV-2 infection and replication of host cells. Dantrolene, as an inhibitor of RyRs, is expected to ameliorate these detrimental effects of SARS-CoV-2 in host cells. Additionally, dantrolene has also been shown to inhibit multiple cell or organ damage induced by hypoxia/ischemia, mitochondria damage, oxidative stresses, inflammation, impairment of autophagy and apoptosis, etc., which are often the causes of severity and mortality of COVID-19 patients. We have repurposed that dantrolene has a high potential at treating COVID-19 patients and reducing its morbidity and mortality.
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影响因子：
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