Bovine telomere dynamics and the association between telomere length and productive lifespan.
Bovine telomere dynamics and the association between telomere length and productive lifespan.
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DOI：
10.1038/s41598-018-31185-z
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发表时间：
2018-08-24
影响因子：
4.6
通讯作者：
Banos G
中科院分区：
文献类型：
--
作者：
Seeker LA;Ilska JJ;Psifidi A;Wilbourn RV;Underwood SL;Fairlie J;Holland R;Froy H;Salvo-Chirnside E;Bagnall A;Whitelaw B;Coffey MP;Nussey DH;Banos G
在一系列脊椎动物物种中，血细胞中的平均端粒长度（TL）已被证明会随着年龄的增长而下降，并且有证据表明TL是与人类晚年健康和死亡率相关的可遗传性状。在非人类哺乳动物中，迄今为止很少有研究检查了终身端粒动态，也没有研究估计了TL的遗传性，尽管这些是评估TL作为家畜物种生产寿命和健康的生物标志物的潜力的重要步骤。在这里，我们测量了308头荷斯坦黑白花奶牛的1,328个样品和38头母牛的284个样品的相对白细胞TL（RLTL）。我们发现RLTL在出生后下降，但在成年后保持相对稳定。我们还计算了一个家畜物种的RLTL的第一遗传力估计值，分别为0.38（SE = 0.03）和0.32（SE = 0.08）的奶牛和小牛数据集。一岁和五岁时测量的RLTL与生产寿命正相关（p < 0.05）。我们的结论是，牛的RLTL是一个可遗传的性状，其与生产寿命可用于育种计划，旨在提高奶牛寿命。
Average telomere length (TL) in blood cells has been shown to decline with age in a range of vertebrate species, and there is evidence that TL is a heritable trait associated with late-life health and mortality in humans. In non-human mammals, few studies to date have examined lifelong telomere dynamics and no study has estimated the heritability of TL, despite these being important steps towards assessing the potential of TL as a biomarker of productive lifespan and health in livestock species. Here we measured relative leukocyte TL (RLTL) in 1,328 samples from 308 Holstein Friesian dairy cows and in 284 samples from 38 female calves. We found that RLTL declines after birth but remains relatively stable in adult life. We also calculated the first heritability estimates of RLTL in a livestock species which were 0.38 (SE = 0.03) and 0.32 (SE = 0.08) for the cow and the calf dataset, respectively. RLTL measured at the ages of one and five years were positively correlated with productive lifespan (p < 0.05). We conclude that bovine RLTL is a heritable trait, and its association with productive lifespan may be used in breeding programmes aiming to enhance cow longevity.
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影响因子：
3.7
作者：
Beirne C;Delahay R;Hares M;Young A
通讯作者：
Young A
影响因子：
2.3
作者：
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通讯作者：
Arnold, Todd W.
影响因子：
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作者：
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DOI：
10.1098/rstb.2016.0436
发表时间：
2018-03-05
期刊：
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子：
--
作者：
Aviv A;Shay JW
通讯作者：
Shay JW
影响因子：
30.8
作者：
Baird, DM;Rowson, J;Kipling, D
通讯作者：
Kipling, D