Metabolic Flexibility of the Heart: The Role of Fatty Acid Metabolism in Health, Heart Failure, and Cardiometabolic Diseases.
Metabolic Flexibility of the Heart: The Role of Fatty Acid Metabolism in Health, Heart Failure, and Cardiometabolic Diseases.
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心脏的代谢灵活性：脂肪酸代谢在健康、心力衰竭和心脏代谢疾病中的作用。
DOI：
10.3390/ijms25021211
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发表时间：
2024-01-19
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
本文综述了脂肪酸（FA）代谢在心脏疾病，特别是心力衰竭（HF）中的重要作用及其治疗策略。心脏对ATP的依赖主要来自线粒体氧化代谢，强调了代谢灵活性的重要性，脂肪酸氧化（FAO）是主要来源。在HF中，代谢变化伴随FA摄取和FAO改变而发生，影响线粒体功能并促进疾病进展。肥胖和糖尿病等疾病也会导致代谢紊乱，导致心肌病，其特征是过度依赖FAO、线粒体功能障碍和脂毒性。针对心脏疾病中FA代谢的治疗方法已经发展，重点是抑制或刺激FAO以优化心脏能量学。策略包括使用CPT1A抑制剂，使用PPARα激动剂，以及增强线粒体生物发生和功能。然而，有效性各不相同，反映了HF代谢重塑的复杂性。因此，考虑到心脏能量代谢是复杂和严格调节的，治疗策略应个体化。治疗的目的是优化整体代谢功能，认识到脂肪酸的关键作用，需要进一步研究开发有效的治疗方法，有希望的新方法靶向线粒体氧化代谢和粮农组织，改善心脏功能。
This comprehensive review explores the critical role of fatty acid (FA) metabolism in cardiac diseases, particularly heart failure (HF), and the implications for therapeutic strategies. The heart’s reliance on ATP, primarily sourced from mitochondrial oxidative metabolism, underscores the significance of metabolic flexibility, with fatty acid oxidation (FAO) being a dominant source. In HF, metabolic shifts occur with an altered FA uptake and FAO, impacting mitochondrial function and contributing to disease progression. Conditions like obesity and diabetes also lead to metabolic disturbances, resulting in cardiomyopathy marked by an over-reliance on FAO, mitochondrial dysfunction, and lipotoxicity. Therapeutic approaches targeting FA metabolism in cardiac diseases have evolved, focusing on inhibiting or stimulating FAO to optimize cardiac energetics. Strategies include using CPT1A inhibitors, using PPARα agonists, and enhancing mitochondrial biogenesis and function. However, the effectiveness varies, reflecting the complexity of metabolic remodeling in HF. Hence, treatment strategies should be individualized, considering that cardiac energy metabolism is intricate and tightly regulated. The therapeutic aim is to optimize overall metabolic function, recognizing the pivotal role of FAs and the need for further research to develop effective therapies, with promising new approaches targeting mitochondrial oxidative metabolism and FAO that improve cardiac function.
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影响因子：
11.1
作者：
Fryk E;Olausson J;Mossberg K;Strindberg L;Schmelz M;Brogren H;Gan LM;Piazza S;Provenzani A;Becattini B;Lind L;Solinas G;Jansson PA
通讯作者：
Jansson PA
影响因子：
5.6
作者：
Monroy-Ramirez HC;Galicia-Moreno M;Sandoval-Rodriguez A;Meza-Rios A;Santos A;Armendariz-Borunda J
通讯作者：
Armendariz-Borunda J
DOI：
10.1016/j.bbalip.2016.03.020
发表时间：
2016-10-01
影响因子：
4.8
作者：
Fukushima, Arata;Lopaschuk, Gary D.
通讯作者：
Lopaschuk, Gary D.
影响因子：
9.7
作者：
Chaanine, Antoine H.;Joyce, Lyle D.;Redfield, Margaret M.
通讯作者：
Redfield, Margaret M.
影响因子：
39.3
作者：
Da Dalt L;Castiglioni L;Baragetti A;Audano M;Svecla M;Bonacina F;Pedretti S;Uboldi P;Benzoni P;Giannetti F;Barbuti A;Pellegatta F;Indino S;Donetti E;Sironi L;Mitro N;Catapano AL;Norata GD
通讯作者：
Norata GD