Human genetics. The genetics of Mexico recapitulates Native American substructure and affects biomedical traits.
Human genetics. The genetics of Mexico recapitulates Native American substructure and affects biomedical traits.
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DOI：
10.1126/science.1251688
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发表时间：
2014-06-13
期刊：
影响因子：
--
通讯作者：
Bustamante CD
中科院分区：
文献类型：
--
作者：
Moreno-Estrada A;Gignoux CR;Fernández-López JC;Zakharia F;Sikora M;Contreras AV;Acuña-Alonzo V;Sandoval K;Eng C;Romero-Hidalgo S;Ortiz-Tello P;Robles V;Kenny EE;Nuño-Arana I;Barquera-Lozano R;Macín-Pérez G;Granados-Arriola J;Huntsman S;Galanter JM;Via M;Ford JG;Chapela R;Rodriguez-Cintron W;Rodríguez-Santana JR;Romieu I;Sienra-Monge JJ;del Rio Navarro B;London SJ;Ruiz-Linares A;Garcia-Herrera R;Estrada K;Hidalgo-Miranda A;Jimenez-Sanchez G;Carnevale A;Soberón X;Canizales-Quinteros S;Rangel-Villalobos H;Silva-Zolezzi I;Burchard EG;Bustamante CD
墨西哥拥有巨大的文化和种族多样性，但该地区人类全基因组变异的精细模式在很大程度上仍然没有特征。我们研究了墨西哥境内代表20个土著和11个混血人口的1,000多人的基因组变异。我们发现墨西哥境内的土著人口在不同程度的地理隔离显着的遗传分层。有些群体的差异就像欧洲人与东亚人的差异一样。前哥伦布时期的基因结构在全国各地的混血混血人的土著祖先中得到了重现。此外，墨西哥人和墨西哥裔美国人的两个独立的表型队列显示了亚大陆血统和肺功能之间的显着关联。因此，解释精细尺度的祖先模式对于墨西哥境内、墨西哥裔人群以及世界上许多其他人群的医学和人群遗传学研究至关重要。
Mexico harbors great cultural and ethnic diversity, yet fine-scale patterns of human genome-wide variation from this region remain largely uncharacterized. We studied genomic variation within Mexico from over 1,000 individuals representing 20 indigenous and 11 mestizo populations. We found striking genetic stratification among indigenous populations within Mexico at varying degrees of geographic isolation. Some groups were as differentiated as Europeans are from East Asians. Pre-Columbian genetic substructure is recapitulated in the indigenous ancestry of admixed mestizo individuals across the country. Furthermore, two independently phenotyped cohorts of Mexicans and Mexican Americans showed a significant association between sub-continental ancestry and lung function. Thus, accounting for fine-scale ancestry patterns is critical for medical and population genetic studies within Mexico, in Mexican-descent populations, and likely in many other populations worldwide.
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影响因子：
3.7
作者：
Gorostiza, Amaya;Acunha-Alonzo, Victor;Gonzalez-Martin, Antonio
通讯作者：
Gonzalez-Martin, Antonio
影响因子：
4.5
作者：
Moreno-Estrada A;Gravel S;Zakharia F;McCauley JL;Byrnes JK;Gignoux CR;Ortiz-Tello PA;Martínez RJ;Hedges DJ;Morris RW;Eng C;Sandoval K;Acevedo-Acevedo S;Norman PJ;Layrisse Z;Parham P;Martínez-Cruzado JC;Burchard EG;Cuccaro ML;Martin ER;Bustamante CD
通讯作者：
Bustamante CD
影响因子：
4.5
作者：
Johnson NA;Coram MA;Shriver MD;Romieu I;Barsh GS;London SJ;Tang H
通讯作者：
Tang H
影响因子：
9.8
作者：
Nalls, Michael A.;Wilson, James G.;Ziv, Elad
通讯作者：
Ziv, Elad
DOI：
10.1056/nejmoa0907897
发表时间：
2010-07-22
期刊：
The New England journal of medicine
影响因子：
--
作者：
Kumar R;Seibold MA;Aldrich MC;Williams LK;Reiner AP;Colangelo L;Galanter J;Gignoux C;Hu D;Sen S;Choudhry S;Peterson EL;Rodriguez-Santana J;Rodriguez-Cintron W;Nalls MA;Leak TS;O'Meara E;Meibohm B;Kritchevsky SB;Li R;Harris TB;Nickerson DA;Fornage M;Enright P;Ziv E;Smith LJ;Liu K;Burchard EG
通讯作者：
Burchard EG