A Model of Arterial Adaptation to Alterations in Blood Flow
A Model of Arterial Adaptation to Alterations in Blood Flow
复制标题
动脉适应血流变化的模型
DOI：
10.1023/a:1010800703478
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
A. Rachev
中科院分区：
文献类型：
--
作者：
A. Rachev
通过将所提出的理论模型的预测与可用的实验数据进行比较，测试了动脉对血流速率变化的适应机制。动脉被建模为由非线性、不可压缩的弹性材料制成的弹性膜。通过产生周向应力的活性成分来模拟血管平滑肌的刺激。肌张力由动脉内皮感知的血流引起的剪切应力调节，并负责响应血流变化而对变形动脉直径进行血管舒缩调节。这项研究提出了这样的假设：导致动脉尺寸变化的平滑肌细胞的合成和增殖活性是剪切应力依赖性的，并且与平滑肌细胞的收缩状态的变化和周壁应力的变化相关。流量阶跃变化的重构被表述为一阶自主微分方程组的初值问题，用于肌肉张力的演化和动脉几何形状的演化。对控制方程进行数值求解，以获得从文献中可用的实验数据确定的模型参数。发现几何尺寸随时间变化及其渐近值的模型预测与现有实验数据定性一致。讨论了验证所引入的假设和模型的进一步推广的实验。
Mechanisms of arterial adaptation to changes in blood flow rates were tested by comparing the predictions of a proposed theoretical model with available experimental data. The artery was modeled as an elastic membrane made of a nonlinear, incompressible, elastic material. Stimulation of the vascular smooth muscle was modeled through the generation of an active component of circumferential stress. The muscular tone was modulated by flow-induced shear stress sensed by the arterial endothelium, and is responsible for the vasomotor adjustment of the deformed arterial diameter in response to changes in blood flow. This study addresses the hypothesis that the synthetic and proliferative activity of smooth muscle cells, leading to a change in arterial dimensions, is shear stress dependent and is associated with changes in the contractile state of the smooth muscle cells and changes in the circumferential wall stress. Remodeling to a step change in flow was formulated as an initial-value problem for a system of first order autonomous differential equations for the evolution of muscular tone and evolution of arterial geometry. The governing equations were solved numerically for model parameters identified from experimental data available in the literature. The model predictions for the time variation of the geometrical dimensions and their asymptotic values were found to be in qualitative agreement with available experimental data. Experiments for validating the introduced hypotheses and further generalizations of the model were discussed.
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影响因子：
20.1
作者：
Reusch, P;Wagdy, H;Ives, HE
通讯作者：
Ives, HE
龟结肠顶端 Na 通道的胆碱能调节：CDPC 诱导的波动分析。
DOI：
10.1152/ajpcell.1990.259.4.c668
发表时间：
1990
期刊：
The American journal of physiology
影响因子：
--
作者：
Wilkinson,DJ;Dawson,DC
通讯作者：
Dawson,DC
影响因子：
--
作者：
BRAYDEN, JE
通讯作者：
BRAYDEN, JE
亚甲蓝和 ETYA 可阻断犬股动脉的血流依赖性扩张。
DOI：
10.1152/ajpheart.1986.250.6.h974
发表时间：
1986
期刊：
The American journal of physiology
影响因子：
--
作者：
Kaiser,L;HullJr,SS;SparksJr,HV
通讯作者：
SparksJr,HV
DOI：
10.1115/1.2798001
发表时间：
1998-06-01
影响因子：
1.7
作者：
Taber, LA
通讯作者：
Taber, LA