Adenoviral-Vectored Centralized Consensus Hemagglutinin Vaccine Provides Broad Protection against H2 Influenza a Virus.
Adenoviral-Vectored Centralized Consensus Hemagglutinin Vaccine Provides Broad Protection against H2 Influenza a Virus.
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DOI：
10.3390/vaccines10060926
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发表时间：
2022-06-10
期刊：
影响因子：
7.8
通讯作者：
Weaver, Eric A.
中科院分区：
文献类型：
--
作者：
Petro-Turnquist, Erika M.;Bullard, Brianna L.;Pekarek, Matthew J.;Weaver, Eric A.
上个世纪发生了几次流感大流行，其中一次是1957年由禽类宿主将H2N2人畜共患传播到人类。这次大流行造成200万至400万人死亡，并一直传播到1968年。自从H2N2从人群中消失以来，人们对H2的免疫力已经减弱，目前这种亚型尚未纳入季节性疫苗中。然而，H2型流感仍然是一个大流行威胁，因为在禽库中持续传播。在这里，我们描述了一种通过创建腺病毒载体的集中共识疫苗设计来预防人类H2流感大流行的方法。我们还评估了血清型转换的效用，以增强同源启动增强策略所见的保护性免疫反应。H2集中式一致性免疫显示出疫苗接种后广泛的抗体应答，对不同的人类H2菌株的攻击具有保护作用，并且在攻击后显著降低了肺部的病毒载量。此外，两种C腺病毒之间的血清型转换在异种增强后增强了保护性抗体滴度。这些数据支持腺病毒载体H2集中式共识疫苗能够提供广泛的交叉反应性免疫应答，以预防不同的H2流感毒株，并为可能的大流行做好准备。
Several influenza pandemics have occurred in the past century, one of which emerged in 1957 from a zoonotic transmission of H2N2 from an avian reservoir into humans. This pandemic caused 2–4 million deaths and circulated until 1968. Since the disappearance of H2N2 from human populations, there has been waning immunity against H2, and this subtype is not currently incorporated into seasonal vaccines. However, H2 influenza remains a pandemic threat due to consistent circulation in avian reservoirs. Here, we describe a method of pandemic preparedness by creating an adenoviral-vectored centralized consensus vaccine design against human H2 influenza. We also assessed the utility of serotype-switching to enhance the protective immune responses seen with homologous prime-boosting strategies. Immunization with an H2 centralized consensus showed a wide breadth of antibody responses after vaccination, protection against challenge with a divergent human H2 strain, and significantly reduced viral load in the lungs after challenge. Further, serotype switching between two species C adenoviruses enhanced protective antibody titers after heterologous boosting. These data support the notion that an adenoviral-vectored H2 centralized consensus vaccine has the ability to provide broadly cross-reactive immune responses to protect against divergent strains of H2 influenza and prepare for a possible pandemic.
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DOI：
10.1056/nejmoa2105290
发表时间：
2021-12-16
期刊：
The New England journal of medicine
影响因子：
--
作者：
Falsey AR;Sobieszczyk ME;Hirsch I;Sproule S;Robb ML;Corey L;Neuzil KM;Hahn W;Hunt J;Mulligan MJ;McEvoy C;DeJesus E;Hassman M;Little SJ;Pahud BA;Durbin A;Pickrell P;Daar ES;Bush L;Solis J;Carr QO;Oyedele T;Buchbinder S;Cowden J;Vargas SL;Guerreros Benavides A;Call R;Keefer MC;Kirkpatrick BD;Pullman J;Tong T;Brewinski Isaacs M;Benkeser D;Janes HE;Nason MC;Green JA;Kelly EJ;Maaske J;Mueller N;Shoemaker K;Takas T;Marshall RP;Pangalos MN;Villafana T;Gonzalez-Lopez A;AstraZeneca AZD1222 Clinical Study Group
通讯作者：
AstraZeneca AZD1222 Clinical Study Group
影响因子：
5.4
作者：
Carter, Donald M.;Darby, Christopher A.;Ross, Ted M.
通讯作者：
Ross, Ted M.
影响因子：
3.7
作者：
Kothe, Denise L.;Li, Yingying;Hahn, Beatrice H.
通讯作者：
Hahn, Beatrice H.
影响因子：
4.4
作者：
Talaat KR;Karron RA;Liang PH;McMahon BA;Luke CJ;Thumar B;Chen GL;Min JY;Lamirande EW;Jin H;Coelingh KL;Kemble GW;Subbarao K
通讯作者：
Subbarao K
来自中国东部家鸭的新型重配甲型流感病毒 (H2N2) 的特征。
影响因子：
4.6
作者：
Ma MJ;Yang XX;Qian YH;Zhao SY;Hua S;Wang TC;Chen SH;Ma GY;Sang XY;Liu LN;Wu AP;Jiang TJ;Gao YW;Gray GC;Zhao T;Ling X;Wang JL;Lu B;Qian J;Cao WC
通讯作者：
Cao WC