Characterization of a novel reassortant influenza A virus (H2N2) from a domestic duck in Eastern China.
Characterization of a novel reassortant influenza A virus (H2N2) from a domestic duck in Eastern China.
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来自中国东部家鸭的新型重配甲型流感病毒 (H2N2) 的特征。
DOI：
10.1038/srep07588
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发表时间：
2014-12-23
影响因子：
4.6
通讯作者：
Cao WC
中科院分区：
文献类型：
--
作者：
Ma MJ;Yang XX;Qian YH;Zhao SY;Hua S;Wang TC;Chen SH;Ma GY;Sang XY;Liu LN;Wu AP;Jiang TJ;Gao YW;Gray GC;Zhao T;Ling X;Wang JL;Lu B;Qian J;Cao WC
虽然H2N2病毒偶尔从野生和家禽中分离出来，但自1968年以来，H2N2病毒尚未在人类中发现。如果H2N2病毒适应家禽，它们可能会对人类构成感染风险，因为大多数1968年以后出生的人都可能容易感染它们。我们报告了2013年从中国无锡市活禽市场的健康家鸭中分离到一种新型甲型流感病毒（H2N2）。序列分析表明，该病毒与欧亚系禽流感病毒相似，在禽类中已流行≥ 2年，α 2，6结合亲和力增强，不具有高致病性。从同一地区取样的100只健康鸡中，约有9%的鸡对H2抗原的抗体升高。幸运的是，很少有血清学证据表明该病毒正在感染家禽工人或已适应感染其他哺乳动物。这些发现表明，一种新的H2N2病毒已在中国无锡市家禽中传播，并具有一定的增强的人类受体亲和力。在中国活禽市场对新型流感病毒进行更好的监测似乎是明智的。
While H2N2 viruses have been sporadically isolated from wild and domestic birds, H2N2 viruses have not been detected among human populations since 1968. Should H2N2 viruses adapt to domestic poultry they may pose a risk of infection to people, as most anyone born after 1968 would likely be susceptible to their infection. We report the isolation of a novel influenza A virus (H2N2) cultured in 2013 from a healthy domestic duck at a live poultry market in Wuxi City, China. Sequence data revealed that the novel H2N2 virus was similar to Eurasian avian lineage avian influenza viruses, the virus had been circulating for ≥ two years among poultry, had an increase in α2,6 binding affinity, and was not highly pathogenic. Approximately 9% of 100 healthy chickens sampled from the same area had elevated antibodies against the H2 antigen. Fortunately, there was sparse serological evidence that the virus was infecting poultry workers or had adapted to infect other mammals. These findings suggest that a novel H2N2 virus has been circulating among domestic poultry in Wuxi City, China and has some has increased human receptor affinity. It seems wise to conduct better surveillance for novel influenza viruses at Chinese live bird markets.
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影响因子：
11.8
作者：
Bi Y;Fu G;Chen J;Peng J;Sun Y;Wang J;Pu J;Zhang Y;Gao H;Ma G;Tian F;Brown IH;Liu J
通讯作者：
Liu J
人类感染新型禽源甲型流感 (H7N9) 病毒。
影响因子：
158.5
作者：
Gao, Rongbao;Cao, Bin;Shu, Yuelong
通讯作者：
Shu, Yuelong
影响因子：
88.1
作者：
Medina, Rafael A.;Garcia-Sastre, Adolfo
通讯作者：
Garcia-Sastre, Adolfo
影响因子：
3.7
作者：
Fan, Shufang;Deng, Guohua;Chen, Hualan
通讯作者：
Chen, Hualan
影响因子：
168.9
作者：
Claas, ECJ;Osterhaus, ADME;Webster, RG
通讯作者：
Webster, RG