Effect of housing rats in dim light or long nights on heart rate.
Effect of housing rats in dim light or long nights on heart rate.
复制标题
在昏暗的灯光或长夜中圈养大鼠对心率的影响。
DOI：
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发表时间：
2008
影响因子：
1.7
通讯作者：
D. Lawson
中科院分区：
文献类型：
--
作者：
T. Azar;J. Sharp;D. Lawson
将实验动物安置在更接近自然环境的照明条件下，可能会改善它们的健康状况。本研究考察了暗光或长夜光循环对大鼠静息心率（HR）的影响及其对急性手术的HR反应。将SD大鼠和自发性高血压大鼠分别置于10 lx照度的12:12 h光：暗光循环（暗光）或200 lx照度的8:16 h光：暗光循环（长夜）下，与单独置于200 lx照度的12:12 h光：暗光循环的对照大鼠进行比较。昏暗光照和长夜显著降低了未受干扰SD和SHR雄性大鼠和SHR雌性大鼠在白天和夜间的HR；然而，未受干扰的SD雌性的HR不受影响。当大鼠遭受急性饲养、实验或应激过程时，昏暗的光线或漫长的夜晚（或两者兼而有之）降低了对某些过程的HR反应，对其他过程的反应没有改变，而对其他过程的反应却增加了。不同品系和雌雄大鼠之间的影响模式各不相同。由于大鼠在10 lx光照或8:16 h明暗光循环下的基础HR降低，我们得出结论，在12:12 h明暗、200 lx环境光条件下饲养的大鼠具有潜在的应激性。我们还得出结论，昏暗的光线或漫长的夜晚并没有均匀地降低急性手术引起的增加的HR反应。
Housing laboratory animals under lighting conditions that more closely mimic the natural environment may improve their wellbeing. This study examined the effects of dim light or a long-night photocycle on resting heart rate (HR) of rats and their HR responses to acute procedures. Male and female Sprague-Dawley (SD) and spontaneously hypertensive (SHR) rats, instrumented with radiotelemetry transmitters and housed individually under a 12:12-h light:dark photocycle with 10 lx illumination (dim light) or under an 8:16-h light:dark photocycle with 200 lx illumination (long nights), were compared with control rats individually housed under a 12:12-h light:dark photocycle with 200 lx illumination. Dim light and long nights significantly reduced the HR of undisturbed SD and SHR male and SHR female rats during the day and at night; however, the HR of undisturbed SD females was not affected. When rats were subjected acutely to husbandry, experimental, or stressful procedures, dim light or long nights (or both) reduced HR responses to some procedures, did not alter responses to others, and increased responses to yet other procedures. The pattern of effects varied between strains and between male and female rats. Because basal HR was reduced when rats were housed under 10 lx illumination or an 8:16-h light:dark photocycle, we concluded that housing rats under 12:12-h light:dark, 200 lx ambient light conditions was potentially stressful, We also concluded that dim light or long nights did not uniformly reduce the increased HR responses induced by acute procedures.
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大鼠对常见程序的应激反应：动情周期的影响。
DOI：
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发表时间：
2002
期刊：
Contemporary topics in laboratory animal science
影响因子：
--
作者：
Sharp,JodyL;Zammit,TimothyG;Lawson,DavidM
通讯作者：
Lawson,DavidM
雄性与雌性自发性高血压大鼠对常见手术的应激样心血管反应。
DOI：
--
发表时间：
2005
期刊：
Contemporary topics in laboratory animal science
影响因子：
--
作者：
Azar,Toni;Sharp,Jody;Lawson,David
通讯作者：
Lawson,David
SHR Y 染色体可提高社交大鼠的夜间血压。
DOI：
10.1152/ajpheart.2000.279.1.h58
发表时间：
2000
期刊：
American journal of physiology. Heart and circulatory physiology
影响因子：
--
作者：
Caplea,A;Seachrist,D;Dunphy,G;Ely,D
通讯作者：
Ely,D
DOI：
10.1152/ajpregu.1998.274.2.r510
发表时间：
1998-02-01
影响因子：
2.8
作者：
Chandler, MP;DiCarlo, SE
通讯作者：
DiCarlo, SE
笼子大小是否会影响雄性大鼠在休息时或在诱发应激样反应的手术后的心率和血压？
DOI：
--
发表时间：
2003
期刊：
Contemporary topics in laboratory animal science
影响因子：
--
作者：
Sharp,Jody;Azar,Toni;Lawson,David
通讯作者：
Lawson,David