SHR Y chromosome enhances the nocturnal blood pressure in socially interacting rats.
SHR Y chromosome enhances the nocturnal blood pressure in socially interacting rats.
复制标题
SHR Y 染色体可提高社交大鼠的夜间血压。
DOI：
10.1152/ajpheart.2000.279.1.h58
复制
发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Ely,D
中科院分区：
文献类型：
--
作者：
Caplea,A;Seachrist,D;Dunphy,G;Ely,D
本研究的目的是验证以下假设：1）与单个笼内大鼠相比，自发性高血压大鼠（SHR）Y染色体品系（SHR/y群体）的夜间平均动脉压（MAP）、心率（HR）和活动量增加。使用无线电遥测监测MAP、HR和活动。SHR/y群体夜间MAP升高（P< 0.05）。SHR Y染色体在殖民地组和笼舍组均显著高于WKY组（P< 0.001）。SHR/y群体动物在MAP >120 mmHg下度过23%的24小时周期，而WKY群体动物在此范围内度过2%的24小时周期。可乐定组SHR/y群体的MAP降低（P< 0.001）至WKY基线值。与笼养动物相比，WKY和SHR/y群体的活动增加（P< 0.01），但心率不变。总之，与单独笼舍相比，群体住房和SHR Y染色体增加MAP。
Our objective was to test the hypothesis that nocturnal mean arterial pressure (MAP), heart rate (HR), and activity would be increased in1) colony over individually caged rats and2) the spontaneously hypertensive rat (SHR) Y chromosome strain (SHR/y colony) compared with Wistar-Kyoto (WKY) rats. MAP, HR, and activity were monitored using radiotelemetry. The nocturnal MAP rise expressed as the percentage change in MAP from light to dark was increased (P< 0.05) in the SHR/y colony. The SHR Y chromosome increased MAP in both the colony and caged groups compared with WKY (P< 0.001). The SHR/y colony animals spent 23% of a 24-h period at a MAP >120 mmHg, whereas the WKY colony animals spent 2% of a 24-h period in this range. The MAP of the SHR/y colony on clonidine was reduced (P< 0.001) to WKY baseline values. Activity but not HR was increased (P< 0.01) in the WKY and SHR/y colonies compared with caged animals. In conclusion, colony housing and the SHR Y chromosome increased MAP compared with individually caged housing.
登录
查看更多内容
血压正常和高血压大鼠群体的生理和神经内分泌与社会地位的相关性。
DOI：
--
发表时间：
1997
期刊：
Acta physiologica Scandinavica. Supplementum
影响因子：
--
作者：
Ely,D;Caplea,A;Dunphy,G;Smith,D
通讯作者：
Smith,D
自发性高血压大鼠和 Wistar-Kyoto 大鼠动脉血压和心率昼夜变化的自主控制。
影响因子：
4.9
作者：
P. Friberg;B. Karlsson;M. Nordlander
通讯作者：
M. Nordlander
影响因子：
8.3
作者：
ELY, DL;DANESHVAR, H;SALISBURY, RL
通讯作者：
SALISBURY, RL
初始心血管结构变化与日间和夜间血压监测之间的关系。
影响因子：
3.2
作者：
D. Rizzoni;M. Muiesan;Giovanni Montani;R. Zulli;S. Calebich;E. Agabiti
通讯作者：
E. Agabiti
影响因子：
8.3
作者：
Schillaci, G;Verdecchia, P;Porcellati, C
通讯作者：
Porcellati, C