Comparison of octreotide LAR and lanreotide autogel as post-operative medical treatment in acromegaly.
Comparison of octreotide LAR and lanreotide autogel as post-operative medical treatment in acromegaly.
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DOI：
10.1007/s11102-011-0335-y
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发表时间：
2012-09
期刊：
影响因子：
3.8
通讯作者：
Guler, Serdar
中科院分区：
文献类型：
--
作者：
Tutuncu, Yasemin;Berker, Dilek;Isik, Serhat;Ozuguz, Ufuk;Akbaba, Gulhan;Kucukler, Ferit Kerim;Aydin, Yusuf;Guler, Serdar
长效生长抑素类似物常用于肢端肥大症患者非治愈性手术后的辅助治疗。本研究旨在比较奥曲肽长效释放剂（OCT）和兰瑞肽自凝胶（LAN）治疗肢端肥大症的疗效。回顾性分析了2003年至2009年期间68例经蝶窦内窥镜或显微镜垂体手术未治愈的患者（25例男性; 43例女性;平均年龄41.1 ± 10.9岁[范围18 - 65岁]）。将患者随机分为OCT组（n = 36）和LAN组（n = 32）。评估包括胰岛素样生长因子I（IGF-I）和生长激素（GH）口服葡萄糖耐量试验（OGTT）后3，6，12和18个月开始药物治疗;垂体磁共振成像进行治疗前和治疗后3个月和12个月。IGF-I水平在年龄和性别正常范围内且OGTT后GH水平<1 μ g/l的患者被认为是"生化治愈"。在开始药物治疗前的术后阶段，LAN组和OCT组的平均IGF-I和GH值以及肿瘤体积（cm3）相似。每次随访访视时，两个治疗组的GH和IGF-I水平与既往值相比均出现统计学显著性降低。两组治疗12个月后的肿瘤缩小具有统计学显著性，但OCT组和LAN组的肿瘤缩小百分比（28.5% vs. 34.9%，P = 0.166）和实现生化治愈的患者比例（63.9%和78.1%，P = 0.454）分别相似。OCT和LAN治疗方案在确保接受非治愈性手术的肢端肥大症患者的生化治愈和肿瘤缩小方面具有相似的疗效。
Long-acting somatostatin analogs are frequently used as adjuvant treatment of acromegaly patients after noncurative surgery. This sudy aims to compare the efficacy of octreotide long-acting release (OCT) and lanreotide Autogel (LAN) in acromegaly patients. Sixty-eight patients not cured by transsphenoidal endoscopic or microscopic pituitary surgery between 2003 and 2009 were retrospectively analyzed (25 men; 43 women; mean age 41.1 ± 10.9 years [range 18–65 years]). The patients were assigned randomly to OCT (n = 36) and LAN (n = 32) groups. Evaluations included insulin-like growth factor I (IGF-I) and growth hormone (GH) after oral glucose tolerance test (OGTT) 3, 6, 12 and 18 months after starting medical treatment; pituitary magnetic resonance imaging was performed before treatment and after 3 and 12 months. Patients achieving IGF-I levels within the age and gender normal range and GH level <1 μg/l following OGTT were considered a ‘biochemical cure’. Mean IGF-I and GH values and tumor volumes (cm3) in the LAN and OCT groups were similar in the post-operative period before initiation of medical treatment. A statistically significant decrease in GH and IGF-I levels was obtained for both treatment groups at each follow-up visit compared to the previous value. Tumor shrinkage after 12 months of treatment was statistically significant in both groups but the percentage tumor shrinkage (28.5% vs. 34.9%, P = 0.166) and rate of patients achieving biochemical cure (63.9 and 78.1%, P = 0.454) were similar between OCT and LAN groups, respectively. OCT and LAN treatment options have similar efficacy for ensuring biochemical cure and tumor shrinkage in acromegaly patients who had noncurative surgery.
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影响因子：
3.2
作者：
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通讯作者：
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