Inhibition of nitric oxide synthase does not prevent ocular dominance plasticity in kitten visual cortex.
Inhibition of nitric oxide synthase does not prevent ocular dominance plasticity in kitten visual cortex.
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一氧化氮合酶的抑制不会阻止小猫视觉皮层的眼部优势可塑性。
DOI：
10.1113/jphysiol.1996.sp021510
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Stryker,MP
中科院分区：
文献类型：
--
作者：
Ruthazer,ES;Gillespie,DC;Dawson,TM;Snyder,SH;Stryker,MP
1.神经信使分子一氧化氮(NO)参与多种形式的可塑性，包括海马长时程增强。在关键时期，我们研究了皮质内长期注入一氧化氮合酶(NOS)活性抑制物对单眼眼睑缝合后视觉皮质反应可塑性的影响。2.用一氧化氮合酶抑制剂(30 mM NG-甲基-L-精氨酸或22或2 mM硝基-L-精氨酸(L-NOArg))和生理盐水处理的巴比妥酸盐麻醉的临界期猫(n=8)的单单位记录均显示出明显的偏向非剥夺眼的改变。一氧化氮合酶被抑制的大脑半球和生理盐水控制的大脑半球的移位幅度相似。3.随后对记录的同一皮质组织中的NOS活性的分析表明，抑制剂处理的大脑半球中的NOS活性显著降低。在所有单个单位记录的区域(距输液套管3 mm处)，22 mM L-NOArg可使一氧化氮合酶活性降低至对照半球的5.55+/-5.33%。L-NOArg(2 MM)和L-NMMA(30 MM)对一氧化氮合酶活性也有明显的抑制作用，但抑制程度较小。4.这些结果表明，一氧化氮合酶活性不是视觉皮层眼优势可塑性所必需的。
1. The neural messenger molecule nitric oxide (NO) has been shown to be involved in several forms of plasticity including hippocampal long‐term potentiation. We examined the effects of chronic intracortical infusion of inhibitors of NO synthase (NOS) activity on the plasticity of visual cortical responses following monocular lid suture during the critical period. 2. Single unit recordings (618 cells) made in both the NOS inhibitor‐treated (30 mM NG‐methyl‐L‐arginine (L‐NMMA), or 22 or 2 mM nitro‐L‐arginine (L‐NOArg)) and saline‐treated control hemispheres of barbiturate‐anaesthetized, critical‐period kittens (n = 8) revealed a profound shift in favour of the non‐deprived eye. Shifts were of similar magnitude in hemispheres in which NOS was inhibited and in saline control hemispheres. 3. Subsequent analysis of NOS activity in the same cortical tissue in which recordings had been made showed a pronounced decrease in NOS activity in inhibitor‐treated hemispheres. In the region in which all the single unit recordings were made (< 3 mm from the infusion cannula), 22 mM L‐NOArg resulted in a reduction of NOS activity to 5.55 +/‐ 5.33% of control hemisphere NOS activity levels. L‐NOArg (2 mM) and L‐NMMA (30 mM) also produced clear, but smaller, inhibition of NOS activity. 4. These findings demonstrate that NOS activity is not essential for ocular dominance plasticity in visual cortex.
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DOI：
10.1073/pnas.88.14.6368
发表时间：
1991-07-01
影响因子：
11.1
作者：
DAWSON, VL;DAWSON, TM;SNYDER, SH
通讯作者：
SNYDER, SH
一氧化氮合酶抑制剂阻断大鼠海马切片生理脑温度下弱但非强强直刺激诱导的长时程增强
影响因子：
2.5
作者：
J. Haley;P. Malen;P. Chapman
通讯作者：
P. Chapman
影响因子：
21.1
作者：
S. Moncada;R. Palmer;E. Higgs
通讯作者：
S. Moncada;R. Palmer;E. Higgs
抑制一氧化氮合酶不会损害空间学习
影响因子：
6.2
作者：
D. Bannerman;PF Chapman;P. Kelly;S. Butcher;R. Morris
通讯作者：
R. Morris
DOI：
10.1073/pnas.88.24.11285
发表时间：
1991-12-01
影响因子：
11.1
作者：
ODELL, TJ;HAWKINS, RD;ARANCIO, O
通讯作者：
ARANCIO, O