Nitric oxide synthase inhibitors block long-term potentiation induced by weak but not strong tetanic stimulation at physiological brain temperatures in rat hippocampal slices
Nitric oxide synthase inhibitors block long-term potentiation induced by weak but not strong tetanic stimulation at physiological brain temperatures in rat hippocampal slices
复制标题
一氧化氮合酶抑制剂阻断大鼠海马切片生理脑温度下弱但非强强直刺激诱导的长时程增强
DOI：
10.1016/0304-3940(93)90919-c
复制
发表时间：
1993
影响因子：
2.5
通讯作者：
P. Chapman
中科院分区：
文献类型：
--
作者：
J. Haley;P. Malen;P. Chapman
一氧化氮合酶（NOS）抑制剂已被证明可以阻止哺乳动物海马体的长期突触增强。然而，这种效应存在一些争议，它表现出对温度和刺激强度的敏感性。我们已经证明 NOS 抑制剂 L-NG-硝基精氨酸 (NOArg) 对大鼠海马切片中弱和强强直刺激诱导的长时程增强 (LTP) 具有不同的作用。 NOArg 阻止弱破伤风诱导 LTP，在对照切片中产生稳定的增强作用，而当使用强破伤风时，NOS 抑制剂则没有作用。这些结果表明，强直刺激产生的一氧化氮 (NO) 在调节 LTP 诱导阈值中发挥作用，但对于在强突触激活条件下建立突触增强来说并不是必需的。
Nitric oxide synthase (NOS) inhibitors have been shown to block long-term synaptic enhancements in the mammalian hippocampus. This effect has been somewhat controversial, however, showing sensitivity to both temperature and stimulus strength. We have demonstrated a differential effect of the NOS inhibitor L-NG-nitroarginine (NOArg) on long-term potentiation (LTP) induced by weak and strong tetanic stimulation in slices of rat hippocampus. NOArg prevented LTP induction by a weak tetanus that produced stable potentiation in control slices, while the NOS inhibitor was without effect when strong tetani were used. These results suggest that nitric oxide (NO) produced as a result of tetanic stimulation plays a role in adjusting the threshold of LTP induction, but is not necessary for establishing synaptic enhancement under conditions of strong synaptic activation.
DOI：
10.1073/pnas.88.24.11285
发表时间：
1991-12-01
影响因子：
11.1
作者：
ODELL, TJ;HAWKINS, RD;ARANCIO, O
通讯作者：
ARANCIO, O
DOI：
10.1016/0006-291x(91)90403-t
发表时间：
1991-05-15
影响因子：
3.1
作者：
DWYER, MA;BREDT, DS;SNYDER, SH
通讯作者：
SNYDER, SH