Decoding Melanoma Development and Progression: Identification of Therapeutic Vulnerabilities.
Decoding Melanoma Development and Progression: Identification of Therapeutic Vulnerabilities.
复制标题
DOI：
10.3389/fonc.2020.626129
复制
发表时间：
2020
影响因子：
4.7
通讯作者：
Chen S
中科院分区：
文献类型：
--
作者：
Eddy K;Shah R;Chen S
黑色素瘤是一种皮肤癌，由转化的黑色素细胞引起。黑色素瘤在所有癌症中具有最高的突变负荷，部分归因于紫外线诱导的DNA损伤。局部黑色素瘤可以通过手术切除“治愈”，然后进行放射治疗以消除任何残留的癌细胞。针对MAPK信号级联的组分的靶向疗法和阻断免疫检查点的免疫疗法已经显示出显著的临床应答，然而随着大多数患者中耐药性的发生和疾病复发，这些患者最终变得难以治疗。虽然我们对包括黑色素瘤在内的癌症转移过程的理解已经取得了很大的进展，但治疗失败表明，关于肿瘤转移的多步骤过程仍有许多需要了解和理解的地方。在这篇综述中，我们提供了一个概述黑素细胞转化为恶性黑色素瘤和关键的分子事件，发生在这一演变。更好地理解导致癌细胞扩散的复杂过程将改善机制驱动的治疗设计，这些治疗针对癌症转移中涉及的特定步骤，以提高所有癌症患者的临床应答率和总生存率。
Melanoma, a cancer of the skin, arises from transformed melanocytes. Melanoma has the highest mutational burden of any cancer partially attributed to UV induced DNA damage. Localized melanoma is “curable” by surgical resection and is followed by radiation therapy to eliminate any remaining cancer cells. Targeted therapies against components of the MAPK signaling cascade and immunotherapies which block immune checkpoints have shown remarkable clinical responses, however with the onset of resistance in most patients, and, disease relapse, these patients eventually become refractory to treatments. Although great advances have been made in our understanding of the metastatic process in cancers including melanoma, therapy failure suggests that much remains to be learned and understood about the multi-step process of tumor metastasis. In this review we provide an overview of melanocytic transformation into malignant melanoma and key molecular events that occur during this evolution. A better understanding of the complex processes entailing cancer cell dissemination will improve the mechanistic driven design of therapies that target specific steps involved in cancer metastasis to improve clinical response rates and overall survival in all cancer patients.
登录
查看更多内容
影响因子：
4.6
作者：
Das A;Monteiro M;Barai A;Kumar S;Sen S
通讯作者：
Sen S
影响因子：
4.2
作者：
Baines AT;Xu D;Der CJ
通讯作者：
Der CJ
影响因子：
2.1
作者：
Black, Jennifer O.
通讯作者：
Black, Jennifer O.
影响因子：
9
作者：
Balch, CM;Soong, SJ;Wanebo, HJ
通讯作者：
Wanebo, HJ
影响因子：
21.3
作者：
Costa-Silva B;Aiello NM;Ocean AJ;Singh S;Zhang H;Thakur BK;Becker A;Hoshino A;Mark MT;Molina H;Xiang J;Zhang T;Theilen TM;García-Santos G;Williams C;Ararso Y;Huang Y;Rodrigues G;Shen TL;Labori KJ;Lothe IM;Kure EH;Hernandez J;Doussot A;Ebbesen SH;Grandgenett PM;Hollingsworth MA;Jain M;Mallya K;Batra SK;Jarnagin WR;Schwartz RE;Matei I;Peinado H;Stanger BZ;Bromberg J;Lyden D
通讯作者：
Lyden D