GADD45β stabilized by direct interaction with HSP72 ameliorates insulin resistance and lipid accumulation.
GADD45β stabilized by direct interaction with HSP72 ameliorates insulin resistance and lipid accumulation.
复制标题
GADD45β 通过与 HSP72 直接相互作用而稳定，改善胰岛素抵抗和脂质积累。
DOI：
10.1016/j.phrs.2021.105879
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Jin Ren
中科院分区：
文献类型：
--
作者：
Yunxia Dong;Ningning Ma;Lei Fan;Luyang Yuan;Qian Wu;Likun Gong;Zhouteng Tao;Jing Chen;Jin Ren
Growth arrest and DNA damage-inducible 45β (GADD45β) belongs to the GADD45 family which is small acidic proteins in response to cellular stress. GADD45β has already been reported to have excellent capabilities against cancer, innate immunity and neurological diseases. However, there is little information regard GADD45β and non-alcoholic fatty liver disease (NAFLD). In the current work, we found that the expression of GADD45β was markedly decreased in the livers of NAFLD patients via analyzing Gene Expression Omnibus (GEO) dataset and in mouse model through detecting its mRNA in high-fat-high-fructose diet (HFHFr)-fed mice. Moreover, the results from in vivo experiment demonstrated that overexpression of GADD45β by AAV8-mediated gene transfer in HFHFr-fed mouse model could reduce the level of serum and hepatic triglyceride (TG), and alleviate insulin resistance. Subsequently, by combining immunoprecipitation (IP) and mass spectrometry, we identified that HSP72 directly interacted with GADD45β to prevent GADD45β from being degraded by the proteasome pathway. Finally, the benefits of GADD45β in regulating key factors of TG synthesis and insulin signaling pathway were abolished after HSP72 knockdown. In conclusion, GADD45β stabilized by the interaction with HSP72 could alleviate the NAFLD-related pathologies, suggested it might be a potential target for the treatment of NAFLD.
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影响因子：
3.7
作者：
Baker SS;Baker RD;Liu W;Nowak NJ;Zhu L
通讯作者：
Zhu L
影响因子：
82.9
作者：
Friedman SL;Neuschwander-Tetri BA;Rinella M;Sanyal AJ
通讯作者：
Sanyal AJ
DOI：
10.1002/9781119432401.ch9
发表时间：
2020-02
期刊：
Heat Stress Tolerance in Plants
影响因子：
--
作者：
Annu Yadav;Jitender Singh;K. Ranjan;Pankaj Kumar;Shivani Khanna;Madhuri Gupta;Vinay Kumar;S. H. Wani;Anil Sirohi
通讯作者：
Annu Yadav;Jitender Singh;K. Ranjan;Pankaj Kumar;Shivani Khanna;Madhuri Gupta;Vinay Kumar;S. H. Wani;Anil Sirohi
影响因子：
7.3
作者：
Xiao-Yi Zeng;Hao Wang;Fang Bai;Xiu Zhou;Songpei Li;Lu-ping Ren;Ruo-Qiong Sun;Charlie C. L. Xue-Charlie-C.-L.-Xu
通讯作者：
Xiao-Yi Zeng;Hao Wang;Fang Bai;Xiu Zhou;Songpei Li;Lu-ping Ren;Ruo-Qiong Sun;Charlie C. L. Xue-Charlie-C.-L.-Xu
影响因子：
13.5
作者：
Kim, Jung-Hwan;Qu, Aijuan;Reddy, Janardan K.;Gao, Bin;Gonzalez, Frank J.
通讯作者：
Gonzalez, Frank J.