The Analytic Identification of Variance Component Models Common to Behavior Genetics.
The Analytic Identification of Variance Component Models Common to Behavior Genetics.
复制标题
行为遗传学常见的方差分量模型的分析识别。
DOI:
10.1007/s10519-021-10055-x
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发表时间:
2021-07
影响因子:
2.6
通讯作者:
Rodgers JL
中科院分区:
文献类型:
--
作者:
Hunter MD;Garrison SM;Burt SA;Rodgers JL
Many behavior genetics models follow the same general structure. We describe this general structure and analytically derive simple criteria for its identification. In particular, we find that variance components can be uniquely estimated whenever the relatedness matrices that define the components are linearly independent (i.e., not confounded). Thus, we emphasize determining which variance components can be identified given a set of genetic and environmental relationships, rather than the estimation procedures. We validate the identification criteria with several well-known models, and further apply them to several less common models. The first model distinguishes child-rearing environment from extended family environment. The second model adds a gene-by-common-environment interaction term in sets of twins reared apart and together. The third model separates measured-genomic relatedness from the scanner site variation in a hypothetical functional magnetic resonance imaging study. The computationally easy analytic identification criteria allow researchers to quickly address model identification issues and define novel variance components, facilitating the development of new research questions.
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