Sequential Loss of Two Neighboring Exons of the Tropoelastin Gene During Primate Evolution
Sequential Loss of Two Neighboring Exons of the Tropoelastin Gene During Primate Evolution
复制标题
灵长类动物进化过程中原弹性蛋白基因两个相邻外显子的连续丢失
DOI：
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发表时间：
1999
影响因子：
3.9
通讯作者：
C. Boyd
中科院分区：
文献类型：
--
作者：
Z. Szabó;S. Levi;A. Christiano;Carole Struminger;M. Stoneking;M. Batzer;C. Boyd
抽象的。先前的证据已经证明在人原弹性蛋白（ELN）基因的3′端内缺少外显子34和35。这些外显子编码原弹性蛋白内的保守多肽结构域，并且在从鸡到大鼠到牛的脊椎动物物种中的ELN基因中发现。我们已经分析了各种灵长类物种的ELN基因，以确定人类外显子34和35的缺失是否是由于人类群体中的等位基因变异，或者是灵长类目的一般特征。对几种非人灵长类动物和来自不同种族背景的人类的546条染色体的ELN基因3′端的分析表明，在灵长类动物进化过程中，外显子34和35连续丢失。外显子35的缺失发生在至少3500万至4500万年前，当时卡他鼻猴从扁鼻猴（新世界猴）分化出来。相比之下，外显子34的丢失只发生在大约600万到800万年前，当时人属从与黑猩猩和大猩猩共享的共同祖先中分离出来。这两个外显子的丢失可能是促进了ESTA介导的重组事件，并可能赋予弹性组织的功能进化优势。
Abstract. Previous evidence has demonstrated the absence of exons 34 and 35 within the 3′ end of the human tropoelastin (ELN) gene. These exons encode conserved polypeptide domains within tropoelastin and are found in the ELN gene in vertebrate species ranging from chickens to rats to cows. We have analyzed the ELN gene in a variety of primate species to determine whether the absence of exons 34 and 35 in humans either is due to allelic variation within the human population or is a general characteristic of the Primates order. An analysis of the 3′ end of the ELN gene in several nonhuman primates and in 546 chromosomes from humans of varying ethnic background demonstrated a sequential loss of exons 34 and 35 during primate evolution. The loss of exon 35 occurred at least 35–45 million years ago, when Catarrhines diverged from Platyrrhines (New World monkeys). Exon 34 loss, in contrast, occurred only about 6–8 million years ago, when Homo separated from the common ancestor shared with chimpanzees and gorillas. Loss of both exons was probably facilitated by Alu-mediated recombination events and possibly conferred a functional evolutionary advantage in elastic tissue.
DOI：
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发表时间：
1989-05
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
M. Bashir;Z. Indik;H. Yeh;N. Ornstein-Goldstein;J. Rosenbloom;W. Abrams;M. Fazio;J. Uitto;J. Rosenbloom
通讯作者：
M. Bashir;Z. Indik;H. Yeh;N. Ornstein-Goldstein;J. Rosenbloom;W. Abrams;M. Fazio;J. Uitto;J. Rosenbloom
DOI：
10.1165/ajrcmb/5.3.206
发表时间：
1991-09-01
影响因子：
6.4
作者：
KAGAN, HM;TRACKMAN, PC
通讯作者：
TRACKMAN, PC