Individuals with mild-to-moderate hip osteoarthritis have lower limb muscle strength and volume deficits.
Individuals with mild-to-moderate hip osteoarthritis have lower limb muscle strength and volume deficits.
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DOI：
10.1186/s12891-018-2230-4
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发表时间：
2018-08-21
影响因子：
2.3
通讯作者：
Barrett R
中科院分区：
文献类型：
--
作者：
Loureiro A;Constantinou M;Diamond LE;Beck B;Barrett R
患有晚期髋关节骨关节炎（OA）的个体表现出患肢的全身性肌无力，因此临床实践指南推荐力量训练用于髋关节OA的管理。然而，在疾病的早期阶段，肌肉无力的程度和模式，包括任何肢体之间的不对称性尚不清楚。本研究比较了髋关节和膝关节肌肉力量和体积之间的个人与轻度至中度症状和影像学髋关节OA和健康对照组。19名患有轻度至中度症状和影像学髋关节OA的个体（n = 12单侧; n = 7双侧）和23名年龄匹配的健康对照，无影像学髋关节OA或髋关节疼痛。测量髋关节和膝关节屈肌和伸肌以及髋关节外展肌和内收肌的等长肌力。髋关节和大腿肌肉体积测量下肢磁共振图像。使用全因子、双向一般线性模型评估组间和肢体间的差异。与对照组相比，髋关节OA组的参与者膝屈肌、膝伸肌、髋屈肌、髋伸肌和髋外展肌强度显著降低，内收肌、腘绳肌和四头肌组以及臀大肌和臀小肌的体积显著降低，但阔筋膜张肌或臀中肌的体积不降低。两组之间没有肢体力量差异或体积差异。萎缩性双侧髋关节和膝关节肌肉无力是轻度至中度髋关节OA患者的特征。早期干预，以针对肌肉无力，并防止力量不对称的发展，是先进的髋关节OA的特点似乎是必要的。
Individuals with advanced hip osteoarthritis (OA) exhibit generalized muscle weakness of the affected limb and so clinical practice guidelines recommend strength training for the management of hip OA. However, the extent and pattern of muscle weakness, including any between-limb asymmetries, in early stages of the disease are unclear. This study compared hip and knee muscle strength and volumes between individuals with mild-to-moderate symptomatic and radiographic hip OA and a healthy control group. Nineteen individuals with mild-to-moderate symptomatic and radiographic hip OA (n = 12 unilateral; n = 7 bilateral) and 23 age-matched, healthy controls without radiographic hip OA or hip pain participated. Isometric strength of the hip and knee flexors and extensors, and hip abductors and adductors were measured. Hip and thigh muscle volumes were measured from lower limb magnetic resonance images. A full-factorial, two-way General Linear Model was used to assess differences between groups and between limbs. Participants in the hip OA group demonstrated significantly lower knee flexor, knee extensor, hip flexor, hip extensor and hip abductor strength compared to controls and had significantly lower volume of the adductor, hamstring and quadriceps groups, and gluteus maximus and gluteus minimus muscles, but not tensor fasciae latae or gluteus medius muscles. There were no between-limb strength differences or volume differences within either group. Atrophic, bilateral hip and knee muscle weakness is a feature of individuals with mild-to-moderate hip OA. Early interventions to target muscle weakness and prevent the development of strength asymmetries that are characteristic of advanced hip OA appear warranted.
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影响因子：
5.1
作者：
Lane, N E;Buckwalter, J A
通讯作者：
Buckwalter, J A
影响因子：
6.1
作者：
Eitzen, Ingrid;Fernandes, Linda;Risberg, May Arna
通讯作者：
Risberg, May Arna
影响因子：
4.2
作者：
Klausmeier, Virginia;Lugade, Vipul;Chou, Li-Shan
通讯作者：
Chou, Li-Shan
影响因子：
1.5
作者：
Arnold, Cathy M.;Faulkner, Robert A.
通讯作者：
Faulkner, Robert A.
DOI：
10.1093/gerona/gls149
发表时间：
2012-11-01
影响因子：
5.1
作者：
Carty, Christopher P.;Barrett, Rod S.;Mills, Peter M.
通讯作者：
Mills, Peter M.