Differential Diagnosis of Parotid Gland Tumors: Role of Shear Wave Elastography.

Differential Diagnosis of Parotid Gland Tumors: Role of Shear Wave Elastography.
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DOI:
10.1155/2017/9234672
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发表时间:
2017
影响因子:
--
通讯作者:
Heřman M
Heřman M
中科院分区:
生物学3区
文献类型:
--
作者:
Heřman J;Sedláčková Z;Vachutka J;Fürst T;Salzman R;Vomáčka J;Heřman M

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利用弹性成像参数建立腮腺良恶性肿瘤的预测评分,并与标准超声比较其敏感性和特异性。对124例计划手术的腮腺病变患者进行常规超声、多普勒检查和横波弹性成像检查。并将检查结果与组织学结果进行比较。在我们的队列中有96例良性病变和28例恶性病变。仅肿瘤边缘模糊被证明是恶性肿瘤的一个极好的预测指标,其敏感性为79%,特异性为97%。颈部淋巴结肿大,肿瘤血管化,微钙化存在,回声均匀,双侧发生也可区分良恶性肿瘤。然而,将它们纳入预测模型并没有提高其性能。弹性图参数(刚度最大值和最小值比为最佳)在良性和恶性肿瘤之间也表现出显著差异,但同样,它们的加入并没有显著提高模糊边界分类器的预测能力。尽管弹性成像本身就能很好地区分良性和恶性病变,但当它作为常规超声检查的辅助手段时,它在评估腮腺肿瘤的生物学特性方面几乎没有任何附加价值。
To create a predictive score for the discrimination between benign and malignant parotid tumors using elastographic parameters and to compare its sensitivity and specificity with standard ultrasound. A total of 124 patients with parotid gland lesions for whom surgery was planned were examined using conventional ultrasound, Doppler examination, and shear wave elastography. Results of the examinations were compared with those ones of histology. There were 96 benign and 28 malignant lesions in our cohort. Blurred tumor margin alone proved to be an excellent predictor of malignancy with the sensitivity of 79% and specificity of 97%. Enlarged cervical lymph nodes, tumor vascularisation, microcalcifications presence, homogeneous echogenicity, and bilateral occurrence also discriminated between benign and malignant tumors. However, their inclusion in a predictive model did not improve its performance. Elastographic parameters (the stiffness maxima and minima ratio being the best) also exhibited significant differences between benign and malignant tumors, but again, their inclusion did not significantly improve the predictive power of the blurred margin classifier. Even though elastography satisfactorily distinguishes benign from malignant lesions on its own, it hardly provides any additional value in evaluation of biological character of parotid gland tumors when used as an adjunct to regular ultrasound examination.
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