Transcript maturation in apicomplexan parasites.
Transcript maturation in apicomplexan parasites.
复制标题
顶端复门寄生虫中的转录本成熟。
DOI：
10.1016/j.mib.2014.05.012
复制
发表时间：
2014
影响因子：
5.4
通讯作者：
White,MichaelW
中科院分区：
文献类型：
--
作者：
Suvorova,ElenaS;White,MichaelW
HighlightsGene expression mechanisms downstream of transcriptional initiation in Apicomplexa are highlighted.Deep RNA sequencing has revealed a wealth of RNA processing in Apicomplexa.Parasites have complete splicing machinery, but, how splicing is regulated remains to be determined.Global control of mRNA splicing in Toxoplasma unexpectedly linked to G1 phase checkpoints.The complex life cycles of apicomplexan parasites are associated with dynamic changes of protein repertoire. In Toxoplasma gondii, global analysis of gene expression demonstrates that dynamic changes in mRNA levels unfold in a serial cascade during asexual replication and up to 50% of encoded genes are unequally expressed in development. Recent studies indicate transcription and mRNA processing have important roles in fulfilling the ‘just-in-time’delivery of proteins to parasite growth and development. The prominence of post-transcriptional mechanisms in the Apicomplexa was demonstrated by mechanistic studies of the critical RNA-binding proteins and regulatory kinases. However, it is still early in our understanding of how transcription and post-transcriptional mechanisms are balanced to produce adequate numbers of specialized forms that is required to complete the parasite life cycle.
登录
查看更多内容
影响因子：
14.9
作者：
Eshar S;Allemand E;Sebag A;Glaser F;Muchardt C;Mandel-Gutfreund Y;Karni R;Dzikowski R
通讯作者：
Dzikowski R
PRP8 和 PRP17/CDC40 这两个酵母基因之间存在广泛的遗传相互作用，这两个基因参与前 mRNA 剪接和细胞周期进程。
影响因子：
3.3
作者：
S. Ben;C. Russell;I. Dix;J. Beggs;M. Kupiec
通讯作者：
M. Kupiec
影响因子：
4
作者：
Fox, BA;Bzik, DJ
通讯作者：
Bzik, DJ
恶性疟原虫剪接体 RNA：3 和 5 末端处理。
影响因子：
2.7
作者：
Calvo Eliana;Escobar Javier;Wasserman Moisés
通讯作者：
Wasserman Moisés
影响因子：
4.8
作者：
Dixit, Aparna;Singh, Prashant K.;Sharma, Pushkar
通讯作者：
Sharma, Pushkar