Relation Between Tumor Size and Lymph Node Metastasis According to Subtypes of Breast Cancer.
Relation Between Tumor Size and Lymph Node Metastasis According to Subtypes of Breast Cancer.
复制标题
不同亚型乳腺癌肿瘤大小与淋巴结转移的关系。
DOI：
10.4048/jbc.2021.24.e4
复制
发表时间：
2021-03
影响因子：
2.4
通讯作者：
Nam SJ
中科院分区：
文献类型：
--
作者：
Min SK;Lee SK;Woo J;Jung SM;Ryu JM;Yu J;Lee JE;Kim SW;Chae BJ;Nam SJ
肿瘤大小和淋巴结转移是影响乳腺癌进展的重要因素。我们的目的是分析肿瘤大小和淋巴结转移分子亚型之间的关系，并检查淋巴结转移对总生存率（OS）的影响。我们回顾性分析了2000年至2015年期间在三星医疗中心接受乳房手术的16，552名患者的数据。获得了关于肿瘤大小（浸润性成分的最大直径）、阳性淋巴结数量和分子亚型的信息。我们建立了一个线性回归模型来评估肿瘤大小与淋巴结转移的关系。为了确定淋巴结转移对OS的影响，我们对Np/T（转移淋巴结数量[n]/肿瘤大小[cm]）进行了考克斯比例回归分析。该研究纳入了12，007例患者，中位随访时间为62个月。管腔A型、管腔B型、HER 2型和三阴性乳腺癌（TNBC）亚型的线性回归系数分别为1.043、1.024、0.656和0.435。管腔A和B亚型之间的系数没有观察到显著差异（p = 0.797），而所有其他系数均显示出显著差异。在调整其他风险因素后，各亚型的Np/T风险比（HR）对OS：管腔A（HR，1.134; 95%置信区间[CI]，1.097-1.171; p < 0.001），管腔B（HR，1.049; 95%CI，1.013-1.086; p = 0.007）、HER2（HR，1.069; 95%CI，1.014-1.126; p = 0.013）和TNBC（HR，1.038; 95%CI，1.01-1.067; p = 0.008）。淋巴结转移的发生率根据分子亚型而不同。管腔型的淋巴结转移发生率高于HER 2和TNBC。Np/T的HR在管腔A亚型中最高，在TNBC亚型中最低。
Tumor size and lymph node metastasis are important factors that contribute to the progression of breast cancer. We aimed to analyze the relationship between tumor size and lymph node metastasis molecular subtype and examine the effects of nodal metastasis on overall survival (OS). We retrospectively reviewed the data of 16,552 patients who underwent breast surgery in Samsung Medical Center between 2000 and 2015. Information on tumor size (largest diameter of the invasive component), number of positive lymph nodes, and molecular subtype were obtained. We constructed a linear regression model to evaluate the relationship between tumor size and lymph node metastasis. To determine the effect of nodal metastasis on OS, we performed a Cox proportional regression analysis with Np/T (number of metastatic lymph nodes [n]/tumor size [cm]). This study included 12,007 patients with a median follow-up of 62 months. The linear regression coefficients were 1.043 for luminal A, 1.024 for luminal B, 0.656 for HER2, and 0.435 for triple-negative breast cancer (TNBC) subtypes. No significant difference was observed in the coefficients between the luminal A and B subtypes (p = 0.797), while all other coefficients showed significant difference. After adjusting for other risk factors, the hazard ratio (HR) of Np/T for each subtype was significant for OS: luminal A (HR, 1.134; 95% confidence interval [CI], 1.097–1.171; p < 0.001), luminal B (HR, 1.049; 95% CI, 1.013–1.086; p = 0.007), HER2 (HR, 1.069; 95% CI, 1.014–1.126; p = 0.013), and TNBC (HR, 1.038; 95% CI, 1.01–1.067; p = 0.008). The incidence of lymph node metastasis differed according to molecular subtype. Luminal types have higher incidence of nodal metastasis than HER2 and TNBC. The HR of Np/T was highest in luminal A subtypes and lowest in TNBC subtypes.
登录
查看更多内容
影响因子：
2.4
作者：
Gülben K;Berberoğlu U;Aydoğan O;Kınaş V
通讯作者：
Kınaş V
影响因子：
2.1
作者：
Tresserra, Francisco;Rodriguez, Ignacio;Fabregas, Rafael
通讯作者：
Fabregas, Rafael
影响因子：
8
作者：
Kawai, H;Li, HC;Avraham, HK
通讯作者：
Avraham, HK
影响因子：
3.7
作者：
Zhou, Weizhuang;Quah, Soo T.;Brown, Christopher J.
通讯作者：
Brown, Christopher J.
影响因子：
51.1
作者：
Krag, David N.;Anderson, Stewart J.;Julian, Thomas B.;Brown, Ann M.;Harlow, Seth P.;Costantino, Joseph P.;Ashikaga, Takamaru;Weaver, Donald L.;Mamounas, Eleftherios P.;Jalovec, Lynne M.;Frazier, Thomas G.;Noyes, R. Dirk;Robidoux, Andre;Scarth, Hugh M. C.;Wolmark, Norman
通讯作者：
Wolmark, Norman