Histopathological assessment of prostate cancer bone osteoblastic metastases.
Histopathological assessment of prostate cancer bone osteoblastic metastases.
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DOI：
10.1016/j.juro.2008.04.140
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发表时间：
2008-09
期刊：
影响因子：
--
通讯作者：
Ott SM
中科院分区：
文献类型：
--
作者：
Roudier MP;Morrissey C;True LD;Higano CS;Vessella RL;Ott SM
许多前列腺癌患者出现骨转移，在X光片上显示为成骨细胞，但这些患者骨折的风险较高。这些事件的放射学和临床方面的差异还没有被很好地理解。这项研究的目的是为了更好地描述前列腺癌骨转移的骨过程的组织病理学特征。采用组织形态计量学方法对12例多发性骨转移患者的多部位骨活检进行评估，其中7例接受双膦酸类药物治疗。骨组织形态计量学显示，在个体患者的不同转移部位，癌症引起的骨变化范围很广，从明显的骨密度到明显的骨量减少类型不等。每个转移灶都与不同程度的吸收有关。在所有的活组织检查中，有一半的骨体积减少。骨密度损害主要由矿化不足的编织骨组成，这增加了新生骨的脆性。有趣的是，编织骨是由肿瘤细胞周围的结缔组织基质形成的碱性磷酸酶纺锤形细胞产生的。接受双磷酸盐治疗的患者和未接受双磷酸盐治疗的患者的骨骼反应总体上相似。尽管前列腺癌的骨转移具有成骨本质，但在每个临床成骨患者中发现的溶骨性-骨质疏松性骨损害可能解释了在这些患者中观察到的频繁骨折。此外，编织骨是直接从肿瘤间质而不是从邻近骨表面形成的，这一发现支持了对前列腺癌骨转移异常成骨机制的进一步研究。
Many patients with prostate cancer develop bone metastases that appear osteoblastic on radiographs, yet these patients have an elevated risk of fractures. The discrepancy between the radiological and clinical aspects of those events is not well understood. The purpose of this study was to better characterize the histopathology of bone processes in prostate cancer bone metastases. Histomorphometry was used to evaluate multi-site bone biopsies in each of 12 patients who died with multiple bone metastases, 7 of whom had received bisphosphonate therapy. Bone histomorphometry revealed a wide spectrum of cancer-induced bone changes in different metastatic sites within individual patients, ranging from a pronounced osteodense to a pronounced osteopenic type. Each metastatic lesion was associated with various amounts of resorption. Decreased bone volume was seen in half of all biopsies. Osteodense lesions were largely composed of undermineralized woven bone, which increases frailty of the new bone. Interestingly, woven bone was produced by alkaline phosphatase spindle-shaped cells arising from the connective stroma surrounding tumor cells. Bone response generally was similar in both bisphosphonate-treated patients and those who did not receive bisphosphonate therapy. Despite the osteoblastic nature of bone metastases in prostate cancer, the osteolytic-osteopenic bone lesions found in each clinically osteoblastic patient may explain the frequent fractures observed in these patients. In addition, the finding that woven bone formed directly from the tumor stroma and not from the adjacent bone surface supports further research into the mechanisms of abnormal bone formation in prostate cancer bone metastases.
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DOI：
10.1007/bf00489547
发表时间：
1987-01-01
期刊：
HISTOCHEMISTRY
影响因子：
--
作者：
LIU, C;SANGHVI, R;HOWARD, GA
通讯作者：
HOWARD, GA
影响因子：
3.3
作者：
Roudier, MP;True, LD;Vessella, RL
通讯作者：
Vessella, RL
影响因子：
45.3
作者：
Coleman, RE;Major, P;Cook, R
通讯作者：
Cook, R
影响因子：
2.8
作者：
Plebani, M;Bernardi, D;Sciacovelli, L
通讯作者：
Sciacovelli, L
影响因子：
4
作者：
Thomas, GP;Baker, SUK;Gardiner, EM
通讯作者：
Gardiner, EM