Side effects of analgesia may significantly reduce quality of life in symptomatic multiple myeloma: a cross-sectional prevalence study.
Side effects of analgesia may significantly reduce quality of life in symptomatic multiple myeloma: a cross-sectional prevalence study.
复制标题
镇痛的副作用可能会显着降低症状性多发性骨髓瘤的生活质量：一项横断面患病率研究。
DOI：
10.1007/s00520-014-2358-1
复制
发表时间：
2015-03
影响因子：
3.1
通讯作者：
Ahmedzai, Sam H.
中科院分区：
文献类型：
--
作者：
Sloot, Sarah;Boland, Jason;Snowden, John A.;Ezaydi, Yousef;Foster, Andrea;Gethin, Alison;Green, Tracy;Chopra, Louise;Verhagen, Stans;Vissers, Kris;Engels, Yvonne;Ahmedzai, Sam H.
疼痛是多发性骨髓瘤（MM）患者的常见症状。许多患者依赖镇痛药，特别是阿片类药物，但关于这些药物及其副作用对健康相关生活质量（HRQoL）的影响的信息有限。在一项横断面研究中，对21例因症状性MM住院接受止痛药治疗的患者进行了半结构化访谈。使用欧洲癌症研究和治疗组织（EORTC）QLQ-C30的第29和30项测量HRQoL。患者能够回忆起2种（范围0-4）镇痛药的中位数。他们自发地确定了两个（范围1-5）副作用的中位数归因于他们的镇痛药物。基于EORTC QLQ-C30问题29/30的患者HRQoL评估平均值为48.3（95% CI; 38.7-57.9）/100。在假设情况下，患者的HRQoL评估显著更高：62.6（53.5-71.7）（t检验，p = 0.001），在假设情况下，患者不会出现镇痛剂的任何副作用。本研究首次提供证据表明，镇痛剂的副作用在症状性MM中很常见，可能导致自我报告的HRQoL出现统计学和临床显著性降低。
Pain is a common symptom in patients with multiple myeloma (MM). Many patients are dependent on analgesics and in particular opioids, but there is limited information on the impact of these drugs and their side effects on health-related quality of life (HRQoL). In a cross-sectional study, semi-structured interviews were performed in 21 patients attending the hospital with symptomatic MM on pain medications. HRQoL was measured using items 29 and 30 of the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30. Patients were able to recall a median of two (range 0–4) analgesics. They spontaneously identified a median of two (range 1–5) side effects attributable to their analgesic medications. Patients’ assessment of HRQoL based on the EORTC QLQ-C30 questions 29/30 was mean 48.3 (95 % CI; 38.7–57.9) out of 100. Patients’ assessment of their HRQoL in the hypothetical situation, in which they would not experience any side effects from analgesics, was significantly higher: 62.6 (53.5–71.7) (t test, p = 0.001). This study provides, for the first time, evidence that side effects of analgesics are common in symptomatic MM and may result in a statistically and clinically significant reduction of self-reported HRQoL.
登录
查看更多内容
影响因子：
3.1
作者：
Schmier, JK;Palmer, CS;Gourlay, G
通讯作者：
Gourlay, G
影响因子：
4
作者：
Gregorian, Razmic S., Jr.;Gasik, Alexander;Kavanagh, Shane
通讯作者：
Kavanagh, Shane
影响因子：
4.7
作者：
Boland, Elaine;Eiser, Christine;Snowden, John A.
通讯作者：
Snowden, John A.
影响因子：
3.4
作者：
Gulbrandsen, N;Wisloff, F;Westin, J
通讯作者：
Westin, J
影响因子：
4.7
作者：
Hjalte, Frida;Berggren, Anna-Carin;Hjortsberg, Catharina
通讯作者：
Hjortsberg, Catharina