Novel insights into axon diameter and myelin content in late childhood and adolescence.
Novel insights into axon diameter and myelin content in late childhood and adolescence.
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DOI：
10.1093/cercor/bhac515
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发表时间：
2023-05-09
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影响因子：
--
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儿童晚期和青春期的白色物质微结构发育主要由轴突密度和髓鞘厚度的增加驱动。离体研究表明，轴突直径的增加驱动发育增加轴突密度观察青春期开始。在这项横断面研究中，使用超强梯度磁共振成像扫描仪扫描了50名8-18岁的典型发育参与者。显微结构特性，包括表观轴突直径，髓鞘含量，和g-比率，估计胼胝体的区域。我们观察到年龄相关的差异，髓鞘含量和g-比率。在青春期早期，男性有较大的压部和较低的髓鞘含量在胼胝体和身体，与女性相比。总的来说，这项工作提供了新的见解发展，青春期，和认知相关的个体差异，在发育中的人类大脑的明显轴突直径和髓鞘含量。
White matter microstructural development in late childhood and adolescence is driven predominantly by increasing axon density and myelin thickness. Ex vivo studies suggest that the increase in axon diameter drives developmental increases in axon density observed with pubertal onset. In this cross-sectional study, 50 typically developing participants aged 8–18 years were scanned using an ultra-strong gradient magnetic resonance imaging scanner. Microstructural properties, including apparent axon diameter , myelin content, and g-ratio, were estimated in regions of the corpus callosum. We observed age-related differences in , myelin content, and g-ratio. In early puberty, males had larger in the splenium and lower myelin content in the genu and body of the corpus callosum, compared with females. Overall, this work provides novel insights into developmental, pubertal, and cognitive correlates of individual differences in apparent axon diameter and myelin content in the developing human brain.
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影响因子：
4.2
作者：
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通讯作者：
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