Puberty in the corpus callosum.
Puberty in the corpus callosum.
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DOI：
10.1016/j.neuroscience.2014.01.030
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发表时间：
2014-04-18
期刊：
影响因子：
3.3
通讯作者：
Luders E
中科院分区：
文献类型：
--
作者：
Chavarria MC;Sánchez FJ;Chou YY;Thompson PM;Luders E
青春期是大脑发育的重要时期。白质的生长受到睾酮等性激素的影响，而胼胝体（人脑中最大的白质结构）可能会在青春期荷尔蒙充足的时期发生结构变化。尽管青春期可能比实际年龄更好地预测认知和行为成熟度，但人们对青春期与大脑结构发育的关系知之甚少。因此，我们的目的是确定青春期对胼胝体解剖结构的影响的存在和方向。为此，我们应用先进的基于表面的网格建模来绘制来自规范数据库的 124 名 5-18 岁儿童和青少年（62 名女性和 62 名男性）的大型且匹配良好的样本中胼胝体厚度和青春期之间的相关性。当将胼胝体解剖结构与青春期状态联系起来时，只有正相关达到统计学显着性，表明胼胝体生长随着青春期而进展。在对青春期不同阶段胼胝体解剖结构差异的测试中，根据青春期阶段，胼胝体生长集中在不同位置。青春期不同阶段循环性激素水平的变化可能导致了观察到的效果，显然需要进一步的研究。性激素水平和区域纤维连接的直接量化（最好使用纤维束成像）将揭示激素是否是青春期胼胝体变化的主要驱动因素。这些胼胝体的发现可能导致关于青春期皮质变化的假设，这可能促进或导致半球间连接的变化。
Adolescence is an important period for brain development. White matter growth is influenced by sex hormones such as testosterone, and the corpus callosum—the largest white matter structure in the human brain—may change structurally during the hormone-laden period of adolescence. Little is known about puberty’s relationship to structural brain development, even though pubertal stage may better predict cognitive and behavioral maturity than chronological age. We therefore aimed to establish the presence and direction of pubertal effects on callosal anatomy. For this purpose, we applied advanced surface-based mesh-modeling to map correlations between callosal thickness and pubertal stage in a large and well-matched sample of 124 children and adolescents (62 female and 62 male) aged 5–18 years from a normative database. When linking callosal anatomy to pubertal status, only positive correlations reached statistical significance, indicating that callosal growth advances with puberty. In tests of differences in callosal anatomy at different stages of puberty, callosal growth was concentrated in different locations depending on the pubertal stage. Changing levels of circulating sex hormones during different phases of puberty likely contributed to the observed effects, and further research is clearly needed. Direct quantification of sex hormone levels and regional fiber connectivity—ideally using fiber tractography—will reveal whether hormones are the main drivers of callosal change during puberty. These callosal findings may lead to hypotheses regarding cortical changes during puberty, which may promote or result from changes in interhemispheric connectivity.
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影响因子：
3.7
作者：
Bramen JE;Hranilovich JA;Dahl RE;Chen J;Rosso C;Forbes EE;Dinov ID;Worthman CM;Sowell ER
通讯作者：
Sowell ER
影响因子：
3.7
作者：
Bramen, Jennifer E.;Hranilovich, Jennifer A.;Sowell, Elizabeth R.
通讯作者：
Sowell, Elizabeth R.
影响因子：
10.6
作者：
Chan, TF;Vese, LA
通讯作者：
Vese, LA
DOI：
10.1523/jneurosci.5122-09.2010
发表时间：
2010-08-18
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Luders E;Thompson PM;Toga AW
通讯作者：
Toga AW
影响因子：
25
作者：
Ahmed, Eman I.;Zehr, Julia L.;Schulz, Kalynn M.;Lorenz, Betty H.;DonCarlos, Lydia L.;Sisk, Cheryl L.
通讯作者：
Sisk, Cheryl L.