Potential biological chemistry of hydrogen sulfide (H2S) with the nitrogen oxides.
Potential biological chemistry of hydrogen sulfide (H2S) with the nitrogen oxides.
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DOI：
10.1016/j.freeradbiomed.2012.11.005
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发表时间：
2013-02
影响因子：
7.4
通讯作者：
King, S. Bruce
中科院分区：
文献类型：
--
作者：
King, S. Bruce
硫化氢是许多生物组织中产生的重要气体信号剂，影响许多生理过程。这种生物学特征让人想起一氧化氮，另一种重要的内源合成气体信号分子。硫化氢在体外与一氧化氮或氧化形式的一氧化氮和一氧化氮供体反应，形成与硫化氢和一氧化氮相比表现出不同生物学特性的物质。这些有趣反应的产物可能包括小分子 S-亚硝基硫醇或硝酰基，即一氧化氮的单电子还原形式。另外，亚亚硝酸或亚硝酸盐、结构上类似于亚硝酸和亚硝酸盐的化合物也可以构成反应产物的一部分。与一氧化氮或硫化氢相比，亚亚硝酸和亚亚硝酸盐的化学和生物学仍然不明确。提出了基于硫化氢作为亲核试剂和还原剂与反应性一氧化氮基中间体的能力形成S-亚硝基硫醇、硝酰基和亚硝酸的一般机制。硫化氢反应性似乎很广泛，可能会影响氧化还原控制生物学和化学的许多领域，需要在这个令人兴奋和发展的领域开展更多工作。
Hydrogen sulfide, an important gaseous signaling agent generated in numerous biological tissues, influences many physiological processes. This biological profile appears reminiscent of nitric oxide, another important endogenously synthesized gaseous signaling molecule. Hydrogen sulfide reacts with nitric oxide or oxidized forms of nitric oxide and nitric oxide donors in vitro to form species that display distinct biology compared to both hydrogen sulfide and NO. The products of these interesting reactions may include small molecule S-nitrosothiols or nitroxyl, the one-electron reduced form of nitric oxide. In addition, thionitrous acid or thionitrite, compounds structurally analogous to nitrous acid and nitrite may constitute a portion of the reaction products. Both the chemistry and biology of thionitrous acid and thionitrite, compared to nitric oxide or hydrogen sulfide, remain poorly defined. General mechanisms for the formation of S-nitrosothiols, nitroxyl and thionitrous acid based upon the ability of hydrogen sulfide to act as a nucleophile and reducing agent with reactive nitric oxide-based intermediates are proposed. Hydrogen sulfide reactivity appears extensive and could impact numerous areas of redox controlled biology and chemistry warranting more work in this exciting and developing area.
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影响因子：
15
作者：
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通讯作者：
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影响因子：
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DOI：
10.1016/j.bbrc.2012.02.051
发表时间：
2012-03-16
影响因子：
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作者：
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通讯作者：
Kashfi, Khosrow
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