Effect of Aging on Daily Rhythms of Lactate Metabolism in the Medial Prefrontal Cortex of Male Mice.
Effect of Aging on Daily Rhythms of Lactate Metabolism in the Medial Prefrontal Cortex of Male Mice.
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DOI：
10.1016/j.neuroscience.2020.07.032
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发表时间：
2020-11-10
期刊：
影响因子：
3.3
通讯作者：
Karatsoreos IN
中科院分区：
文献类型：
--
作者：
Wallace NK;Pollard F;Savenkova M;Karatsoreos IN
衰老与睡眠、大脑功能和行为中的昼夜节律的振幅降低和时间提前有关。我们研究了年龄相关的昼夜节律功能障碍是否延伸到大脑的代谢功能，特别是在前额叶皮层（PFC）。使用酶安培生物传感器，我们记录乳酸浓度的变化，在年轻（7个月）和老年（19个月）自由行为的C57 BL/6 J雄性小鼠PFC。青年和老年小鼠表现出昼夜和昼夜节律的乳酸，与老年节律略有提前阶段。在恒定条件下，老年节律显示出在年轻小鼠中未观察到的幅度降低。我们同时观察了唤醒状态和PFC乳酸节律之间的关系，通过脑电图，这是修改的老化。最后，使用RT-qPCR，我们发现衰老影响葡萄糖转运蛋白1的日常表达模式。
Aging is associated with reduced amplitude and earlier timing of circadian (daily) rhythms in sleep, brain function, and behavior. We examined whether age-related circadian dysfunction extends to the metabolic function of the brain, particularly in the prefrontal cortex (PFC). Using enzymatic amperometric biosensors, we recorded lactate concentration changes in the PFC in Young (7 mos) and Aged (19 mos) freely-behaving C57BL/6J male mice. Both Young and Aged mice displayed diurnal and circadian rhythms of lactate, with the Aged rhythm slightly phase advanced. Under constant conditions, the Aged rhythm showed a reduced amplitude not seen in the Young mice. We simultaneously observed a relationship between arousal state and PFC lactate rhythm via electroencephalography, which was modified by aging. Finally, using RT-qPCR, we found that aging affects the daily expression pattern of Glucose Transporter 1.
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