Noncontrast T2-Weighted Magnetic Resonance Imaging Sequences for Long-Term Monitoring of Asymptomatic Convexity Meningiomas.
Noncontrast T2-Weighted Magnetic Resonance Imaging Sequences for Long-Term Monitoring of Asymptomatic Convexity Meningiomas.
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DOI：
10.1016/j.wneu.2019.11.051
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发表时间：
2020-03
影响因子：
2
通讯作者：
Hayden Gephart M
中科院分区：
文献类型：
--
作者：
He JQ;Iv M;Li G;Zhang M;Hayden Gephart M
用于增强MR的钆基造影剂（GBCA）与组织沉积有关，包括在大脑中。惰性肿瘤如脑膜瘤的处理需要频繁的MR来监测间隔生长。考虑到对GBCA沉积的关注，我们试图确定无症状脑膜瘤患者的非增强MR在监测监测中是否等同于GBCA增强MR。IRB批准的回顾性病历审查包括18例患者的106个MR序列。入选标准为接受基线增强和非增强轴位MR成像的无症状脑膜瘤成人患者。排除标准包括：1）基线或随访轴位图像无法用于审查2）基线扫描未使用造影剂3）脑膜瘤的诊断不确定。通过比较最早和最近扫描的最大肿瘤直径处的横截面积来测量肿瘤生长百分比。对于每例患者，使用T1+造影剂、T2和T2 FLAIR序列比较肿瘤大小随时间的变化。将这些与神经外科医生和神经放射科医生的定性共识阅读进行比较。测量的大于10%的变化代表肿瘤生长。在18名患者中，有17名患者的非造影研究（T2和T2 FLAIR）测量结果与共识一致。对于1例患者，T2成像显示生长11%，而T2 FLAIR和总体共识是稳定的。我们的研究提供了证据表明，在无症状脑膜瘤中，非增强MR图像与对比加权MR图像在跟踪肿瘤大小随时间的变化方面是等效的。
Gadolinium based contrast agents (GBCA) used to enhance MRs have been linked to tissue deposition, including in the brain. The management of indolent tumors such as meningiomas requires frequent MRs to monitor for interval growth. Given concern regarding GBCA deposition, we sought to determine if non-contrast MRs in patients with asymptomatic meningiomas were equivalent to GBCA-enhanced MRs in surveillance monitoring. This IRB-approved retrospective chart review included 106 MR sequences from 18 patients. Inclusion criteria were adult patients with asymptomatic meningiomas who received baseline contrast-enhanced and non-contrast axial MR imaging of the brain. Exclusion criteria included: 1) baseline or follow-up axial images were not available for review 2) baseline scan was obtained without contrast 3) diagnosis of meningioma was uncertain. Percent tumor growth was measured by comparing cross-sectional area at maximum tumor diameter from the earliest and most recent scans. For each patient, change in tumor size over time was compared using T1+contrast, T2, and T2 FLAIR sequences. These were compared to a qualitative consensus reading by a neurosurgeon and a neuroradiologist. Measured change of greater than 10% was taken to represent tumor growth. In 17 out of 18 patients, measurement of non-contrast studies (T2 and T2 FLAIR) matched consensus. For one patient, imaging on T2 suggested 11% growth while T2 FLAIR and overall consensus was stability. Our study provides evidence that non-contrasted MR images are equivalent to contrast-weighted MRs to follow change in tumor size over time in asymptomatic meningiomas.
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