Epigenetic Mechanisms in Hematologic Aging and Premalignant Conditions.
Epigenetic Mechanisms in Hematologic Aging and Premalignant Conditions.
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血液学衰老和预调子疾病中的表观遗传机制。
DOI：
10.3390/epigenomes7040032
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发表时间：
2023-12-12
期刊：
影响因子：
2.5
通讯作者：
中科院分区：
文献类型：
--
作者：
造血干细胞（HSC）通过在个体的整个生命周期中持续产生血细胞来维持整体健康。然而，随着年龄的增长，造血系统的功能明显下降，使他们更容易患上与年龄有关的疾病。越来越多的研究证据强调了表观遗传调控在这种与年龄相关的衰退中的关键作用。本文综述了衰老过程中正常造血干细胞调控的表观遗传学机制及其在衰老相关疾病中的意义。了解造血系统中与衰老相关的变化的表观遗传机制的复杂相互作用，对于开发延缓衰老过程的创新策略具有巨大潜力。事实上，针对表观遗传修饰的干预措施在缓解与衰老相关的表型和延长各种动物模型的寿命方面显示出有希望的结果。基于小分子的疗法和重编程策略使表观遗传复壮成为改善甚至逆转衰老相关疾病的有效方法。通过对这些表观遗传机制的更深入了解，预计可以设计干预措施来预防或减轻血液老化和相关疾病的发生率。最终，这些进步有可能改善整体健康状况，提高老年人的生活质量。
Hematopoietic stem cells (HSCs) are essential for maintaining overall health by continuously generating blood cells throughout an individual’s lifespan. However, as individuals age, the hematopoietic system undergoes significant functional decline, rendering them more susceptible to age-related diseases. Growing research evidence has highlighted the critical role of epigenetic regulation in this age-associated decline. This review aims to provide an overview of the diverse epigenetic mechanisms involved in the regulation of normal HSCs during the aging process and their implications in aging-related diseases. Understanding the intricate interplay of epigenetic mechanisms that contribute to aging-related changes in the hematopoietic system holds great potential for the development of innovative strategies to delay the aging process. In fact, interventions targeting epigenetic modifications have shown promising outcomes in alleviating aging-related phenotypes and extending lifespan in various animal models. Small molecule-based therapies and reprogramming strategies enabling epigenetic rejuvenation have emerged as effective approaches for ameliorating or even reversing aging-related conditions. By acquiring a deeper understanding of these epigenetic mechanisms, it is anticipated that interventions can be devised to prevent or mitigate the rates of hematologic aging and associated diseases later in life. Ultimately, these advancements have the potential to improve overall health and enhance the quality of life in aging individuals.
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影响因子：
8.8
作者：
Brown K;Xie S;Qiu X;Mohrin M;Shin J;Liu Y;Zhang D;Scadden DT;Chen D
通讯作者：
Chen D
影响因子：
50.3
作者：
Abdel-Wahab O;Adli M;LaFave LM;Gao J;Hricik T;Shih AH;Pandey S;Patel JP;Chung YR;Koche R;Perna F;Zhao X;Taylor JE;Park CY;Carroll M;Melnick A;Nimer SD;Jaffe JD;Aifantis I;Bernstein BE;Levine RL
通讯作者：
Levine RL
影响因子：
64.8
作者：
Agger, Karl;Cloos, Paul A. C.;Helin, Kristian
通讯作者：
Helin, Kristian
影响因子：
13.6
作者：
Akunuru S;Geiger H
通讯作者：
Geiger H
影响因子：
1.4
作者：
Magilnick N;Boldin MP
通讯作者：
Boldin MP