Intergenerational effects on offspring telomere length: interactions among maternal age, stress exposure and offspring sex
Intergenerational effects on offspring telomere length: interactions among maternal age, stress exposure and offspring sex
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对后代端粒长度的代际影响：母亲年龄、压力暴露和后代性别之间的相互作用
DOI：
10.1098/rspb.2019.1845
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Monaghan, Pat
中科院分区：
文献类型：
--
作者：
Marasco, Valeria;Boner, Winnie;Griffiths, Kate;Heidinger, Britt;Monaghan, Pat
年龄较大的父母所生的后代通常会缩短寿命，这被称为兰辛效应。由于成年人通常有年龄相仿的配偶，很难区分母亲和父亲的年龄的影响，环境环境也可能影响后代的结果。人们对兰辛效应背后的机制知之甚少。在许多脊椎动物中，端粒长度和丢失的变化，特别是在早期生命中，与寿命有关，因此在这方面，后代端粒动力学的变化可能是非常重要的。我们研究了母体年龄和环境对斑雀后代端粒长度的影响。我们让母亲处于控制(随意食物)或更具挑战性(不可预测的食物)的环境中，并通过实验将父亲的年龄和配偶选择的影响降至最低。与母体环境无关，母体年龄对后代端粒长度有显著的负面影响，在纵向和横向比较中很明显(平均短39%)。此外，在年轻母亲中，由有挑战的母亲抚养的儿子的端粒长度明显短于由对照母亲抚养的儿子。当母亲上了年纪时，这种影响就消失了，而在女儿身上也消失了。这些发现突出了端粒动力学作为决定最佳年龄特定生殖努力和性别分配的进化过程的代际中介的重要性。
Offspring produced by older parents often have reduced longevity, termed the Lansing effect. Because adults usually have similar-aged mates, it is difficult to separate effects of maternal and paternal age, and environmental circumstances are also likely to influence offspring outcomes. The mechanisms underlying the Lansing effect are poorly understood. Variation in telomere length and loss, particularly in early life, is linked to longevity in many vertebrates, and therefore changes in offspring telomere dynamics could be very important in this context. We examined the effect of maternal age and environment on offspring telomere length in zebra finches. We kept mothers under either control (ad libitum food) or more challenging (unpredictable food) circumstances and experimentally minimized paternal age and mate choice effects. Irrespective of the maternal environment, there was a substantial negative effect of maternal age on offspring telomere length, evident in longitudinal and cross-sectional comparisons (average of 39% shorter). Furthermore, in young mothers, sons reared by challenged mothers had significantly shorter telomere lengths than sons reared by control mothers. This effect disappeared when the mothers were old, and was absent in daughters. These findings highlight the importance of telomere dynamics as inter-generational mediators of the evolutionary processes determining optimal age-specific reproductive effort and sex allocation.
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影响因子：
4.5
作者：
Bauch, Christina;Boonekamp, Jelle J.;Verhulst, Simon
通讯作者：
Verhulst, Simon
出生环境对生活史影响持续存在的性别差异
影响因子：
9.2
作者：
T. Wilkin;B. Sheldon
通讯作者：
B. Sheldon
日本鹌鹑生殖周期中卵黄睾酮浓度的变化。
DOI：
--
发表时间：
2009
期刊：
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
影响因子：
--
作者：
M. Okuliarová;P. Škrobánek;M. Zeman
通讯作者：
M. Zeman
影响因子：
14.9
作者：
Cawthon, RM
通讯作者：
Cawthon, RM
影响因子：
5.2
作者：
Monaghan, P.;Charmantier, A.;Ricklefs, R. E.
通讯作者：
Ricklefs, R. E.