Nanoparticle approaches against bacterial infections.

Nanoparticle approaches against bacterial infections.
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DOI:
10.1002/wnan.1282
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发表时间:
2014-11
影响因子:
8.6
通讯作者:
Zhang, Liangfang
Zhang, Liangfang
中科院分区:
医学2区
文献类型:
--
作者:
Gao, Weiwei;Thamphiwatana, Soracha;Angsantikul, Pavimol;Zhang, Liangfang

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Despite the wide success of antibiotics, the treatment of bacterial infection still faces significant challenges, particularly the emergence of antibiotic resistance. As a result, nanoparticle drug delivery platforms including liposomes, polymeric nanoparticles, dendrimers, and various inorganic nanoparticles have been increasingly exploited to enhance the therapeutic effectiveness of existing antibiotics. This review focuses on areas where nanoparticle approaches hold significant potential to advance the treatment of bacterial infection. These areas include targeted antibiotic delivery, environmentally responsive antibiotic delivery, combinatorial antibiotic delivery, nanoparticle-enabled antibacterial vaccination, and nanoparticle-based bacterial detection. In each area we highlight the innovative antimicrobial nanoparticle platforms and review their progress made against bacterial infections.
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