HDAC6: A Key Link Between Mitochondria and Development of Peripheral Neuropathy.
HDAC6: A Key Link Between Mitochondria and Development of Peripheral Neuropathy.
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DOI：
10.3389/fnmol.2021.684714
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发表时间：
2021
影响因子：
4.8
通讯作者：
Barton MC
中科院分区：
文献类型：
--
作者：
English K;Barton MC
周围神经病是由于病变或疾病造成的神经损伤，由于神经病理性疼痛的常见表现，它仍然是一个主要的健康问题。大多数关于周围神经病发生发展的研究都集中在电压门控离子通道或谷氨酸受体等关键分子上。然而，新出现的证据表明，线粒体功能障碍是周围神经病和由此导致的神经病理性疼痛的主要参与者。神经病中的线粒体功能障碍包括线粒体转运、线粒体代谢和线粒体动力学改变。导致周围神经病线粒体功能障碍的机制尚不清楚，然而，IIb类组蛋白脱乙酰酶(HDAC6)可能在这一过程中发挥重要作用。HDAC6是线粒体动力学多种机制中的关键调节因子，可能与周围神经病的线粒体失调有关。越来越多的证据表明，在体内和体外周围神经病模型中，HDAC6抑制与减轻周围神经病和神经病理性疼痛以及线粒体功能障碍密切相关。因此，人们正在研究HDAC6抑制剂作为治疗多种周围神经病的潜在疗法。在这里，我们回顾了新出现的研究，并综合了最近的进展，以了解周围神经病变和线粒体功能障碍之间通过HDAC6介导的相互作用之间的独特联系。
Peripheral neuropathy, which is the result of nerve damage from lesions or disease, continues to be a major health concern due to the common manifestation of neuropathic pain. Most investigations into the development of peripheral neuropathy focus on key players such as voltage-gated ion channels or glutamate receptors. However, emerging evidence points to mitochondrial dysfunction as a major player in the development of peripheral neuropathy and resulting neuropathic pain. Mitochondrial dysfunction in neuropathy includes altered mitochondrial transport, mitochondrial metabolism, as well as mitochondrial dynamics. The mechanisms that lead to mitochondrial dysfunction in peripheral neuropathy are poorly understood, however, the Class IIb histone deacetylase (HDAC6), may play an important role in the process. HDAC6 is a key regulator in multiple mechanisms of mitochondrial dynamics and may contribute to mitochondrial dysregulation in peripheral neuropathy. Accumulating evidence shows that HDAC6 inhibition is strongly associated with alleviating peripheral neuropathy and neuropathic pain, as well as mitochondrial dysfunction, in in vivo and in vitro models of peripheral neuropathy. Thus, HDAC6 inhibitors are being investigated as potential therapies for multiple peripheral neuropathic disorders. Here, we review emerging studies and integrate recent advances in understanding the unique connection between peripheral neuropathy and mitochondrial dysfunction through HDAC6-mediated interactions.
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影响因子：
3.3
作者：
Ahn HS;Black JA;Zhao P;Tyrrell L;Waxman SG;Dib-Hajj SD
通讯作者：
Dib-Hajj SD
影响因子：
5.7
作者：
Cho Y;Cavalli V
通讯作者：
Cavalli V
影响因子：
81.5
作者：
Colloca, Luana;Ludman, Taylor;Raja, Srinivasa N.
通讯作者：
Raja, Srinivasa N.
DOI：
10.1093/brain/awx375
发表时间：
2018-03-01
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Benoy V;Van Helleputte L;Prior R;d'Ydewalle C;Haeck W;Geens N;Scheveneels W;Schevenels B;Cader MZ;Talbot K;Kozikowski AP;Vanden Berghe P;Van Damme P;Robberecht W;Van Den Bosch L
通讯作者：
Van Den Bosch L
影响因子：
82.9
作者：
d'Ydewalle, Constantin;Krishnan, Jyothsna;Van Den Bosch, Ludo
通讯作者：
Van Den Bosch, Ludo