A novel retinoic acid, catechin hydrate and mustard oil-based emulsion for enhanced cytokine and antibody responses against multiple strains of HIV-1 following mucosal and systemic vaccinations.
A novel retinoic acid, catechin hydrate and mustard oil-based emulsion for enhanced cytokine and antibody responses against multiple strains of HIV-1 following mucosal and systemic vaccinations.
复制标题
DOI：
10.1016/j.vaccine.2011.01.024
复制
发表时间：
2011-03-16
期刊：
影响因子：
5.5
通讯作者：
Vajdy, Michael
中科院分区：
文献类型：
--
作者：
Yu, Mingke;Vajdy, Michael
非复制的蛋白质或dna抗原通常需要免疫增强佐剂和递送系统。培养针对HIV-1的gp120的抗体尤其困难，这是HIV疫苗设计的重要途径。虽然几乎所有的佐剂研究都集中在模仿病原体和它们在宿主体内产生的危险信号上，但在营养方法上花费的精力相对较少。在本研究中，研究了一种由维生素a、多酚类黄酮儿茶素水合物和芥菜油组成的新的营养性免疫增强递送系统（NIDS）对HIV-1CN54的gp120蛋白免疫应答的辅助作用。在对小鼠进行两次粘膜和两次全身疫苗接种后，我们发现局部和全身抗体以及细胞因子反应都有显著增强。这些数据对设计针对HIV-1和其他病原体的疫苗和佐剂具有重要意义。
Non-replicating protein- or DNA-based antigens generally require immune-enhancing adjuvants and delivery systems. It has been particularly difficult to raise antibodies against gp120 of HIV-1, which constitutes an important approach in HIV vaccine design. While almost all effort in adjuvant research has focused on mimicking the pathogens and the danger signals they engender in the host, relatively little effort has been spent on nutritive approaches. In this study, a new nutritive immune-enhancing delivery system (NIDS) composed of vitamin A, a polyphenol-flavonoid catechin hydrate, and mustard oil was tested for its adjuvant effect in immune responses against the gp120 protein of HIV-1CN54. Following a combination of two mucosal and two systemic vaccinations of mice, we found significant enhancement of both local and systemic antibodies as well as cytokine responses. These data have important implications for vaccine and adjuvant design against HIV-1 and other pathogens.
登录
查看更多内容
影响因子：
3.3
作者：
Mantena, SK;Roy, AM;Katiyar, SK
通讯作者：
Katiyar, SK
影响因子：
3.1
作者：
Baudner, BC;Balland, O;Del Giudice, G
通讯作者：
Del Giudice, G
DOI：
10.1128/cdli.9.3.616-621.2002
发表时间：
2002-05-01
期刊：
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
影响因子：
--
作者：
Jason, J;Archibald, LK;Jarvis, WR
通讯作者：
Jarvis, WR
影响因子：
3.1
作者：
Matsunaga, K;Klein, TW;Yamamoto, Y
通讯作者：
Yamamoto, Y
影响因子：
5.4
作者：
Moore, PL;Crooks, ET;Binley, JM
通讯作者：
Binley, JM