Novel role of RGS2 in regulation of antioxidant homeostasis in neuronal cells.
Novel role of RGS2 in regulation of antioxidant homeostasis in neuronal cells.
复制标题
DOI：
10.1016/j.febslet.2011.04.023
复制
发表时间：
2011-05-06
期刊：
影响因子：
3.5
通讯作者：
Hite B
中科院分区：
文献类型：
--
作者：
Salim S;Asghar M;Taneja M;Hovatta I;Wu YL;Saha K;Sarraj N;Hite B
Regulator of G-protein Signaling Protein (RGS)-2 is a modulator of anxiety and dysregulation of oxidative stress is implicated in anxiety. Also, RGS2 expression is reported to be induced by oxidative stress. Thus, if oxidative stress induces RGS2 expression and lack of RGS2 causes anxiety, then mechanisms that link RGS2 and oxidative stress potentially critical to anxiety must be revealed. Our study is the first to suggest role of RGS2 in regulation of enzymes involved in antioxidant defense namely glyoxalase-1 and glutathione reductase-1 via activation of p38 MAPK and PKC pathways in an Sp-1 dependent manner.
登录
查看更多内容
DOI：
10.1124/jpet.108.137208
发表时间：
2008-08-01
影响因子：
3.5
作者：
Masood, Anbrin;Nadeem, Ahmed;O'Donnell, James M.
通讯作者：
O'Donnell, James M.
影响因子：
3.3
作者：
Kim, Sung Dae;Sung, Hye Jin;Rhee, Man Hee
通讯作者：
Rhee, Man Hee
影响因子：
64.8
作者：
Hovatta, I;Tennant, RS;Barlow, C
通讯作者：
Barlow, C
DOI：
10.1073/pnas.220414397
发表时间：
2000-10-24
影响因子：
11.1
作者：
Oliveira-dos-Santos, AJ;Matsumoto, G;Penninger, JM
通讯作者：
Penninger, JM
影响因子：
--
作者：
Smoller, Jordan W.;Paulus, Martin P.;Stein, Murray B.
通讯作者：
Stein, Murray B.