Applications of orthogonal "click" chemistries in the synthesis of functional soft materials.
Applications of orthogonal "click" chemistries in the synthesis of functional soft materials.
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DOI：
10.1021/cr900138t
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发表时间：
2009-11
期刊：
影响因子：
62.1
通讯作者：
Hawker CJ
中科院分区：
文献类型：
--
作者：
Iha RK;Wooley KL;Nyström AM;Burke DJ;Kade MJ;Hawker CJ
随着纳米技术的发展和对解决资源、健康和能源问题的日益增长的需求，具有精确工程性质和官能团的先进功能软材料的应用已经显著扩展。一系列工业和研究环境中的需求正在增加构建对结构、域尺寸、功能性、极性、溶解度和反应性进行精确控制的软材料系统的必要性。除了这些材料和结构要求之外，研究人员还试图通过高产、简单的共价化学来制备这些系统。构建这种复杂的多功能材料的许多灵感可以在基础有机化学，生物学和生物共轭化学的结合中找到;这些动机与控制聚合技术的最新进展相结合，创造了一个不断增长的研究领域，专注于强大，高效和正交（REO）的新软材料制备方法。这篇综述的目的是总结和强调应用REO化学的软材料的制备和功能化的快速扩展的领域。这篇评论的重点是集中在软材料化学，在功能聚合物的制备和二维聚合物表面和三维聚合物物体的纳米尺寸的修改的主要兴趣。利用这种化学方法对生物实体进行正交修饰，如肽、蛋白质、酶和病毒系统，也将是一种新的方法。
Applications for advanced functional soft materials that possess precisely engineered properties and functional groups have been expanding significantly with the development of nanotechnology and the growing need to address resource, health, and energy issues. Demand in a range of industrial and research settings are increasing the necessity to construct soft material systems with precise control over architecture, domain size, functionality, polarity, solubility, and reactivity. In addition to these materials and structural requirements, researchers have also sought to prepare these systems via high yielding, simple covalent chemistry. Much of the inspiration for constructing such complex, multifunctional materials can be found in a combination of fundamental organic chemistry, biology, and bioconjugation chemistry; these motivations in tandem with the recent advances in controlled polymerization techniques have created a growing research area with concentration on robust, efficient, and orthogonal (REO) approachesfornewsoftmaterialpreparation. The aim of this review is to summarize and highlight the rapidly expanding area of applied REO chemistry for the preparation and functionalization of soft materials. The emphasis of this review is centered on soft materials chemistry, with a primary interest in functional polymer preparation and the modification of two-dimensional polymer surfaces and three-dimensional polymer objects of nanoscopic dimensions. The exploitation of this chemistry for the orthogonal modification of biological entities, such as peptides, proteins, enzymes, and viral systems, will also be
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影响因子：
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